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Effect of Capsaicin Pretreatment on Substance P Binding to Synaptic Vesicles

1980; Wiley; Volume: 35; Issue: 5 Linguagem: Inglês

10.1111/j.1471-4159.1980.tb07881.x

1471-4159

N. Michael Mayer, R. Gamse, F. Lembeck,

Pain Mechanisms and Treatments

Abstract: Newborn or adult rats were pretreated with 50 mg kg –1 capsaicin. At the age of 2 to 4 months, binding of 125 1‐labelled Tyr 8 ‐substance P to synaptic vesicles prepared from different regions of the nervous system was examined. In both groups, capsaicin pretreatment led to a significant decrease in the number of binding sites in dorsal roots and spinal cord without having an effect on affinity. This decrease parallels the depletion of the substance P content (Gamse et al., 1980) and can be explained by degeneration of primary sensory neurons in newborn treated rats and by depletion of vesicles in adult treated rats.