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Cytomegalovirus-Associated Tubulointerstitial Nephritis in an Allogeneic Bone Marrow Transplant Recipient

1987; American College of Physicians; Volume: 107; Issue: 3 Linguagem: Inglês

10.7326/0003-4819-107-2-351

1539-3704

Ronald I. Shorr, Walter Longo, Terry D. Oberley, Marek J. Bozdech, Duard L. Walker,

Drug-Induced Hepatotoxicity and Protection

Brief Reports1 September 1987Cytomegalovirus-Associated Tubulointerstitial Nephritis in an Allogeneic Bone Marrow Transplant RecipientRONALD I. SHORR, M.D., WALTER L. LONGO, M.D., TERRY D. OBERLEY, M.D., MAREK J. BOZDECH, M.D., DUARD L. WALKER, M.D.RONALD I. SHORR, M.D., WALTER L. LONGO, M.D., TERRY D. OBERLEY, M.D., MAREK J. BOZDECH, M.D., DUARD L. WALKER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-2-351 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHematuria is common in complications of the urinary tract after bone marrow transplantation and is related to infections and ablative therapy (1). Hemorrhagic cystitis has been frequently attributed to high-dose cyclophosphamide, but viral agents responsible for the hemorrhage are being recognized. In particular, cytomegalovirus is a frequent cause of infection in bone marrow transplant patients and has commonly been associated with hemorrhagic cystitis. We describe a case in which hemorrhagic cystitis was the initial clinical presentation; other features included glycosuria and proteinuria, and renal biopsy showed a tubulointerstitial nephritis due to cytomegalovirus.A 19-year-old white woman with a...References1. DROLLERSARALSANTOS MRG. Prevention of cyclophosphamide-induced hemorrhagic cystitis. Urology. 1982;20:256-8. CrossrefMedlineGoogle Scholar2. SPITALPANNERSTERNS ABR. Acute idiopathic tubulointerstitial nephritis: report of two cases and review of the literature. Am J Kid Dis. 1987;9:71-8. CrossrefMedlineGoogle Scholar3. MYERS J. Infection in bone marrow transplant recipients. Am J Med. 1986;81(suppl 1A):27-38. CrossrefMedlineGoogle Scholar4. RICHARDSONCOLVINCHEESEMAN WRS. Glomerulopathy associated with cytomegalovirus viremia in renal allografts. N Engl J Med. 1981;305:57-63. CrossrefMedlineGoogle Scholar5. OZAWASTEWART TJ. Immune-complex glomerulonephritis associated with cytomegalovirus infection. Am J Clin Pathol. 1978;72:103-7. CrossrefGoogle Scholar6. ARTHURSHAHBAUSTSANTOSSARAL RKSGR. Association of BK viruria with hemorrhagic cystitis in recipients of bone marrow transplants. N Engl J Med. 1986;315:230-4. CrossrefMedlineGoogle Scholar7. AMBINDERBURNSFORMAN RWM. Hemorrhagic cystitis associated with adenovirus infection in bone marrow transplantation. Arch Intern Med. 1986;146:1400-1. CrossrefMedlineGoogle Scholar8. ROSENHARMONKRENSKY SWA. Tubulo-interstitial nephritis associated with polyoma virus (BK type) infection. N Engl J Med. 1983;308:1192-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RONALD I. SHORR, M.D.; WALTER L. LONGO, M.D.; TERRY D. OBERLEY, M.D.; MAREK J. BOZDECH, M.D.; DUARD L. WALKER, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCytomegalovirus, BK, and Other Viral Infections of the KidneyImmunological Mechanisms of Interstitial DiseaseTHE CLINICAL SIGNIFICANCE OF CYTOMEGALOVIRAL INCLUSIONS IN THE ALLOGRAFT KIDNEYThe enhancer domain of the human cytomegalovirus major immediate-early promoter determines cell type-specific expression in transgenic miceCytomegaloviral virus infection in bone marrow transplantation recipients: strategies for prevention and treatmentCytomegalovirus Infection After Solid Organ TransplantationNephritogenic tubulointerstitial antigensHerpesvirus and Enteric Viral Infections in Bone Marrow Transplantation Clinical Presentations, Pathogenesis, and Therapeutic StrategiesCytomegalovirus infection after organ transplantation: an update with special emphasis on renal transplantationStudy of the immunopathogenesis of tubulointerstitial nephritis using model systemsCytomegalovirus infection after organ transplantation: an update with special emphasis on renal transplantationInfection in Relation to Thoracic Transplantation 1 September 1987Volume 107, Issue 3Page: 351-352KeywordsBone marrowCyclophosphamideCystitisCytomegalovirus infectionHematology and oncologyHemorrhageInfectious diseasesNephritisProteinuriaUrinary tract infections ePublished: 1 December 2008 Issue Published: 1 September 1987 PDF downloadLoading ...