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Synthesis and antiplatelet activity of phenyl quinolones

1998; Elsevier BV; Volume: 6; Issue: 10 Linguagem: Inglês

10.1016/s0968-0896(98)00141-2

1464-3391

Li‐Jiau Huang, Ming-Chieh Hsieh, Che‐Ming Teng, K H Lee, Sheng-Chu Kuo,

Chemical synthesis and pharmacological studies

In our search for novel antiplatelet agents, seven positional phenyl quinolone isomers were synthesized. Preliminary screening confirmed their inhibitory effects against arachidonic acid (AA)-induced platelet aggregation. Varying the substitutional position of the phenyl group had a profound effect on the antiplatelet activity of these isomers. 3-Phenyl-4-quinolone showed the greatest potency and was superior to indomethacin, although the two structures are quite different. The mechanism and pharmacological action of 3-phenyl-4-quinolone are currently under investigation.