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Scaffolded DNA Origami of a DNA Tetrahedron Molecular Container

2009; American Chemical Society; Volume: 9; Issue: 6 Linguagem: Inglês

10.1021/nl901165f

1530-6992

Yonggang Ke, Jaswinder Sharma, Minghui Liu, Kasper Jahn, Yan Liu, Hao Yan,

RNA Interference and Gene Delivery

We describe a strategy of scaffolded DNA origami to design and construct 3D molecular cages of tetrahedron geometry with inside volume closed by triangular faces. Each edge of the triangular face is ∼54 nm in dimension. The estimated total external volume and the internal cavity of the triangular pyramid are about 1.8 × 10−23 and 1.5 × 10−23 m3, respectively. Correct formation of the tetrahedron DNA cage was verified by gel electrophoresis, atomic force microscopy, transmission electron microscopy, and dynamic light scattering techniques.