Increased synthesis of poly(ADP‐ribose) in isolated liver nuclei from autoimmune NZB/NZW mice
1987; Wiley; Volume: 215; Issue: 2 Linguagem: Inglês
10.1016/0014-5793(87)80156-4
ISSN1873-3468
AutoresBrenda L. Haug, John Sibley, Jeremy S. Lee,
Tópico(s)Toxin Mechanisms and Immunotoxins
ResumoThe synthesis and degradation of poly(ADP-ribose) were investigated in isolated liver nuclei from autoimmune NZB/W mice and four strains of normal mice. Compared to normal mice the maximum levels of incorporation of [3H]NAD into poly(ADP-ribose) were increased about 2-fold in the autoimmune mice. The kinetics of incorporation suggested that this change was due to an increase in the activity of the polymerase rather than a decrease in the level of degradative enzymes. Thus there may be a connection between autoimmunity and poly(ADP-ribose) metabolism.
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