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Pharmacokinetics of Oral Nifedipine in Different Populations

1993; Wiley; Volume: 33; Issue: 2 Linguagem: Inglês

10.1002/j.1552-4604.1993.tb03934.x

1552-4604

Gilberto Castañeda‐Hernández, Carlos Hoyo‐Vadillo, José Antonio Palma‐Aguirre, Francisco Javier Flores‐Murrieta,

Drug Transport and Resistance Mechanisms

Nifedipine disposition varies among populations. Reports on oral nifedipine pharmacokinetics show that peak plasma levels and AVC values are higher in Mexican and Japanese than in European and North American subjects. Increased nifedipine bioavailability in the nonwhite populations is likely due to nutritional habits. Certain flavonoids that inhibit the first‐pass metabolism of dihydropyridines are present in the diets of both Mexican and Japanese. Differences in phenotypes may play a role in interethnic variability.