Prediction of creatinine clearance from serum creatinine concentration based on lean body mass
1981; Wiley; Volume: 30; Issue: 3 Linguagem: Inglês
10.1038/clpt.1981.181
ISSN1532-6535
AutoresThierry Hallynck, Hans H Soep, Jozef Thomis, Johann Boelaert, R Daneels, J. P. Fillastre, F. De Rosa, Ethan Rubinstein, M Hatala, J Spousta, L Dettli,
Tópico(s)Antibiotics Pharmacokinetics and Efficacy
ResumoClinical Pharmacology & TherapeuticsVolume 30, Issue 3 p. 414-421 Original Article Prediction of creatinine clearance from serum creatinine concentration based on lean body mass Thierry Hallynck PhD, Thierry Hallynck PhD Department of Microbiology, Faculty of Pharmacy, University of Ghent, Department of Clinical Research, Bristol-Myers International Corporation, Brussels, Sint-Jan Ziekenhuis, Bruges Department of Medicine, University of Rouen, Institute of Infectious Diseases, University of Perugia, Chaim Sheba Medical Centre, University of Tel Aviv, Institute for Clinical and Experimental Medicine, Prague Department of Internal Medicine, University of BaselSearch for more papers by this authorHans H Soep MD, Hans H Soep MD Department of Microbiology, Faculty of Pharmacy, University of Ghent, Department of Clinical Research, Bristol-Myers International Corporation, Brussels, Sint-Jan Ziekenhuis, Bruges Department of Medicine, University of Rouen, Institute of Infectious Diseases, University of Perugia, Chaim Sheba Medical Centre, University of Tel Aviv, Institute for Clinical and Experimental Medicine, Prague Department of Internal Medicine, University of BaselSearch for more papers by this authorJozef Thomis PhD, Jozef Thomis PhD Department of Microbiology, Faculty of Pharmacy, University of Ghent, Department of Clinical Research, Bristol-Myers International Corporation, Brussels, Sint-Jan Ziekenhuis, Bruges Department of Medicine, University of Rouen, Institute of Infectious Diseases, University of Perugia, Chaim Sheba Medical Centre, University of Tel Aviv, Institute for Clinical and Experimental Medicine, Prague Department of Internal Medicine, University of BaselSearch for more papers by this authorJohann Boelaert MD, Johann Boelaert MD Department of Microbiology, Faculty of Pharmacy, University of Ghent, Department of Clinical Research, Bristol-Myers International Corporation, Brussels, Sint-Jan Ziekenhuis, Bruges Department of Medicine, University of Rouen, Institute of Infectious Diseases, University of Perugia, Chaim Sheba Medical Centre, University of Tel Aviv, Institute for Clinical and Experimental Medicine, Prague Department of Internal Medicine, University of BaselSearch for more papers by this authorRoger Daneels MD, Roger Daneels MD Department of Microbiology, Faculty of Pharmacy, University of Ghent, Department of Clinical Research, Bristol-Myers International Corporation, Brussels, Sint-Jan Ziekenhuis, Bruges Department of Medicine, University of Rouen, Institute of Infectious Diseases, University of Perugia, Chaim Sheba Medical Centre, University of Tel Aviv, Institute for Clinical and Experimental Medicine, Prague Department of Internal Medicine, University of BaselSearch for more papers by this authorJean P Fillastre MD, Jean P Fillastre MD Department of Microbiology, Faculty of Pharmacy, University of Ghent, Department of Clinical Research, Bristol-Myers International Corporation, Brussels, Sint-Jan Ziekenhuis, Bruges Department of Medicine, University of Rouen, Institute of Infectious Diseases, University of Perugia, Chaim Sheba Medical Centre, University of Tel Aviv, Institute for Clinical and Experimental Medicine, Prague Department of Internal Medicine, University of BaselSearch for more papers by this authorFranco De Rosa MD, Franco De Rosa MD Department of Microbiology, Faculty of Pharmacy, University of Ghent, Department of Clinical Research, Bristol-Myers International Corporation, Brussels, Sint-Jan Ziekenhuis, Bruges Department of Medicine, University of Rouen, Institute of Infectious Diseases, University of Perugia, Chaim Sheba Medical Centre, University of Tel Aviv, Institute for Clinical and Experimental Medicine, Prague Department of Internal Medicine, University of BaselSearch for more papers by this authorEthan Rubinstein MD, Ethan Rubinstein MD Department of Microbiology, Faculty of Pharmacy, University of Ghent, Department of Clinical Research, Bristol-Myers International Corporation, Brussels, Sint-Jan Ziekenhuis, Bruges Department of Medicine, University of Rouen, Institute of Infectious Diseases, University of Perugia, Chaim Sheba Medical Centre, University of Tel Aviv, Institute for Clinical and Experimental Medicine, Prague Department of Internal Medicine, University of BaselSearch for more papers by this authorMilan Hatala MD, Milan Hatala MD Department of Microbiology, Faculty of Pharmacy, University of Ghent, Department of Clinical Research, Bristol-Myers International Corporation, Brussels, Sint-Jan Ziekenhuis, Bruges Department of Medicine, University of Rouen, Institute of Infectious Diseases, University of Perugia, Chaim Sheba Medical Centre, University of Tel Aviv, Institute for Clinical and Experimental Medicine, Prague Department of Internal Medicine, University of BaselSearch for more papers by this authorJosef Spousta MD, Josef Spousta MD Department of Microbiology, Faculty of Pharmacy, University of Ghent, Department of Clinical Research, Bristol-Myers International Corporation, Brussels, Sint-Jan Ziekenhuis, Bruges Department of Medicine, University of Rouen, Institute of Infectious Diseases, University of Perugia, Chaim Sheba Medical Centre, University of Tel Aviv, Institute for Clinical and Experimental Medicine, Prague Department of Internal Medicine, University of BaselSearch for more papers by this authorLucius Dettli MD, Corresponding Author Lucius Dettli MD Department of Microbiology, Faculty of Pharmacy, University of Ghent, Department of Clinical Research, Bristol-Myers International Corporation, Brussels, Sint-Jan Ziekenhuis, Bruges Department of Medicine, University of Rouen, Institute of Infectious Diseases, University of Perugia, Chaim Sheba Medical Centre, University of Tel Aviv, Institute for Clinical and Experimental Medicine, Prague Department of Internal Medicine, University of BaselDepartment of Internal Medicine, Kantonsspital, 4031 Basel, Switzerland.Search for more papers by this author Thierry Hallynck PhD, Thierry Hallynck PhD Department of Microbiology, Faculty of Pharmacy, University of Ghent, Department of Clinical Research, Bristol-Myers International Corporation, Brussels, Sint-Jan Ziekenhuis, Bruges Department of Medicine, University of Rouen, Institute of Infectious Diseases, University of Perugia, Chaim Sheba Medical Centre, University of Tel Aviv, Institute for Clinical and Experimental Medicine, Prague Department of Internal Medicine, University of BaselSearch for more papers by this authorHans H Soep MD, Hans H Soep MD Department of Microbiology, Faculty of Pharmacy, University of Ghent, Department of Clinical Research, Bristol-Myers International Corporation, Brussels, Sint-Jan Ziekenhuis, Bruges Department of Medicine, University of Rouen, Institute of Infectious Diseases, University of Perugia, Chaim Sheba Medical Centre, University of Tel Aviv, Institute for Clinical and Experimental Medicine, Prague Department of Internal Medicine, University of BaselSearch for more papers by this authorJozef Thomis PhD, Jozef Thomis PhD Department of Microbiology, Faculty of Pharmacy, University of Ghent, Department of Clinical Research, Bristol-Myers International Corporation, Brussels, Sint-Jan Ziekenhuis, Bruges Department of Medicine, University of Rouen, Institute of Infectious Diseases, University of Perugia, Chaim Sheba Medical Centre, University of Tel Aviv, Institute for Clinical and Experimental Medicine, Prague Department of Internal Medicine, University of BaselSearch for more papers by this authorJohann Boelaert MD, Johann Boelaert MD Department of Microbiology, Faculty of Pharmacy, University of Ghent, Department of Clinical Research, Bristol-Myers International Corporation, Brussels, Sint-Jan Ziekenhuis, Bruges Department of Medicine, University of Rouen, Institute of Infectious Diseases, University of Perugia, Chaim Sheba Medical Centre, University of Tel Aviv, Institute for Clinical and Experimental Medicine, Prague Department of Internal Medicine, University of BaselSearch for more papers by this authorRoger Daneels MD, Roger Daneels MD Department of Microbiology, Faculty of Pharmacy, University of Ghent, Department of Clinical Research, Bristol-Myers International Corporation, Brussels, Sint-Jan Ziekenhuis, Bruges Department of Medicine, University of Rouen, Institute of Infectious Diseases, University of Perugia, Chaim Sheba Medical Centre, University of Tel Aviv, Institute for Clinical and Experimental Medicine, Prague Department of Internal Medicine, University of BaselSearch for more papers by this authorJean P Fillastre MD, Jean P Fillastre MD Department of Microbiology, Faculty of Pharmacy, University of Ghent, Department of Clinical Research, Bristol-Myers International Corporation, Brussels, Sint-Jan Ziekenhuis, Bruges Department of Medicine, University of Rouen, Institute of Infectious Diseases, University of Perugia, Chaim Sheba Medical Centre, University of Tel Aviv, Institute for Clinical and Experimental Medicine, Prague Department of Internal Medicine, University of BaselSearch for more papers by this authorFranco De Rosa MD, Franco De Rosa MD Department of Microbiology, Faculty of Pharmacy, University of Ghent, Department of Clinical Research, Bristol-Myers International Corporation, Brussels, Sint-Jan Ziekenhuis, Bruges Department of Medicine, University of Rouen, Institute of Infectious Diseases, University of Perugia, Chaim Sheba Medical Centre, University of Tel Aviv, Institute for Clinical and Experimental Medicine, Prague Department of Internal Medicine, University of BaselSearch for more papers by this authorEthan Rubinstein MD, Ethan Rubinstein MD Department of Microbiology, Faculty of Pharmacy, University of Ghent, Department of Clinical Research, Bristol-Myers International Corporation, Brussels, Sint-Jan Ziekenhuis, Bruges Department of Medicine, University of Rouen, Institute of Infectious Diseases, University of Perugia, Chaim Sheba Medical Centre, University of Tel Aviv, Institute for Clinical and Experimental Medicine, Prague Department of Internal Medicine, University of BaselSearch for more papers by this authorMilan Hatala MD, Milan Hatala MD Department of Microbiology, Faculty of Pharmacy, University of Ghent, Department of Clinical Research, Bristol-Myers International Corporation, Brussels, Sint-Jan Ziekenhuis, Bruges Department of Medicine, University of Rouen, Institute of Infectious Diseases, University of Perugia, Chaim Sheba Medical Centre, University of Tel Aviv, Institute for Clinical and Experimental Medicine, Prague Department of Internal Medicine, University of BaselSearch for more papers by this authorJosef Spousta MD, Josef Spousta MD Department of Microbiology, Faculty of Pharmacy, University of Ghent, Department of Clinical Research, Bristol-Myers International Corporation, Brussels, Sint-Jan Ziekenhuis, Bruges Department of Medicine, University of Rouen, Institute of Infectious Diseases, University of Perugia, Chaim Sheba Medical Centre, University of Tel Aviv, Institute for Clinical and Experimental Medicine, Prague Department of Internal Medicine, University of BaselSearch for more papers by this authorLucius Dettli MD, Corresponding Author Lucius Dettli MD Department of Microbiology, Faculty of Pharmacy, University of Ghent, Department of Clinical Research, Bristol-Myers International Corporation, Brussels, Sint-Jan Ziekenhuis, Bruges Department of Medicine, University of Rouen, Institute of Infectious Diseases, University of Perugia, Chaim Sheba Medical Centre, University of Tel Aviv, Institute for Clinical and Experimental Medicine, Prague Department of Internal Medicine, University of BaselDepartment of Internal Medicine, Kantonsspital, 4031 Basel, Switzerland.Search for more papers by this author First published: September 1981 https://doi.org/10.1038/clpt.1981.181Citations: 7AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give 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Learn more.Copy URL Abstract An equation for predicting endogenous creatinine clearance (CrCl) in adults and children (with both stable and unstable renal function) from serum creatinine concentrations is presented. The predictions are compared with four other available estimating methods, based on values in 110 subjects with renal impairment of widely differing degrees. In patients with stable and with unstable renal function the correlation between measured and predicted CrCl was better with the new equation. In patients with rapidly changing renal function the new equation resulted in accurate predictions of CrCl within a few hours after the change, as opposed to several days with the other methods. The elimination rate constant of the aminoglycoside antibiotic amikacin correlated more precisely with CrCl values estimated from the new equation than with those measured during 24 hr or with the other prediction methods. Clinical Pharmacology and Therapeutics (1981) 30, 414–421; doi:10.1038/clpt.1981.181 Citing Literature Volume30, Issue3September 1981Pages 414-421 RelatedInformation
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