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CELLULAR HETEROGENEITY IN MALIGNANT NEOPLASMS AND THE THERAPY OF METASTASES

1982; Wiley; Volume: 397; Issue: 1 Linguagem: Inglês

10.1111/j.1749-6632.1982.tb43415.x

1749-6632

George Poste,

Pancreatic and Hepatic Oncology Research

Annals of the New York Academy of SciencesVolume 397, Issue 1 p. 34-48 CELLULAR HETEROGENEITY IN MALIGNANT NEOPLASMS AND THE THERAPY OF METASTASES George Poste, Corresponding Author George Poste Smith Kline and French Laboratories Philadelphia, Pennsylvania 19101; and Department of Pathology and Laboratory Medicine University of Pennsylvania, Medical School Philadelphia, Pennsylvania 19104*Address for correspondence: Dr. G. Poste, Smith Kline & French Laboratories, 1500 Spring Garden Street, Philadelphia, Pennsylvania 19101.Search for more papers by this author George Poste, Corresponding Author George Poste Smith Kline and French Laboratories Philadelphia, Pennsylvania 19101; and Department of Pathology and Laboratory Medicine University of Pennsylvania, Medical School Philadelphia, Pennsylvania 19104*Address for correspondence: Dr. G. Poste, Smith Kline & French Laboratories, 1500 Spring Garden Street, Philadelphia, Pennsylvania 19101.Search for more papers by this author First published: December 1982 https://doi.org/10.1111/j.1749-6632.1982.tb43415.xCitations: 9AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Steele, G. G. 1977. Growth Kinetics of Tumors. Clarendon Press. Oxford . 2 Skipper, H. E. 19781980. Cancer Chemotherapy. Vols. 1–4. Southern Research Institute Monographs. University Microfilms International. Dallas , TX . 3 Frei, E., III & G. P. Canellos, 1980. Dose: A critical factor in cancer chemotherapy. Am. J. Med. 69: 585– 597. 4 I. J. Fidler & R. J. White, Eds. 1982. Design of Models for Testing Cancer Therapeutic Agents. Van Nostrand. New York , NY . 5 Poste, G. & I. J. Fidler. 1980. The pathogenesis of cancer metastasis. Nature 283: 139– 146. 6 Fidler, I. J. & G. Poste. 1982. The heterogeneity of metastatic properties in malignant tumor cells and regulation of the metastatic phenotype. In Tumor Cell Heterogeneity. A. Owens, Ed. Academic Press, New York , NY . In press. 7 Weiss, L. 1980. Metastasis: Differences between cancer cells in primary and secondary tumors. Pathobiol. Ann. 10: 51– 81. 8 Koch, F. E. 1939. Zur Frage der Metastasenbildung bei Impftumoren. Krebsforsch. 48: 495– 505. 9 Klein, E. 1955. Gradual transformation of solid into ascites tumors. Evidence favoring the mutation-selection theory. Exp. Cell Res. 8: 188– 199. 10 Fidler, I. J. 1973. Selection of successive tumor lines for metastasis. Nature New Biol. 242: 148– 149. 11 Brunson, K. W., G. Beattie & G. L. Nicolson. 1978. Selection and altered tumour cell properties of brain-colonising metastatic melanoma. Nature 272: 543– 545. 12 Kerbel, R. S., R. R. Twiddy & D. M. Robertson. 1978. Induction of a tumor with greatly increased metastatic growth potential by injection of cells from a low-metastatic H-2 heterozygous tumor cell line into an H-2 incompatible parental strain. Int. J. Cancer 22: 583– 594. 13 Hart, I. R. 1979. The selection and characterization of an invasive variant of the B16 melanoma. Am. J. Pathol. 97: 587– 600. 14 Schirrmacher, V., G. Shantz, K. Clauer, D. Komitowski, H.-P. Zimmermann & M.-L. Lohmann-Matthes. 1979. Tumor metastases and cell-mediated immunity in a model system in DBA/2 mice. I. Tumor invasiveness in vitro and metastasis formation in vivo. Int. J. Cancer 23: 233– 244. 15 Poste, G., J. Doll, I. R. Hart & I. J. Fidler. 1980. In vitro selection of murine B16 melanoma variants with enhanced tissue invasive properties. Cancer Res. 40: 1636– 1644. 16 Fidler, I. J. & M. L. Kripke. 1977. Metastasis results from pre-existing variant cells within a malignant tumor. Science 197: 893– 895. 17 Fidler, I. J., E. Gruys, M. A. Cifone, Z. Barnes & C. Bucana. 1981. Demonstration of multiple phenotypic diversity in a murine melanoma of recent origin. J. Natl. Cancer Inst. 67: 947– 956. 18 Dexter, D. L., H. M. Kowalski, B. A. Blazar, A. Fligiel, R. Vogel & G. H. Heppner. 1978. Heterogeneity of tumor cells from a single mouse mammary tumor. Cancer Res. 38: 3174– 3181. 19 Kripke, M. L., E. Gruys & I. J. Fidler. 1978. Metastatic heterogeneity of cells from an ultraviolet light-induced murine fibrosarcoma of recent origin. Cancer Res. 38: 2962– 2967. 20 Suzuki, N., M. Williams, M. Hunter & H. R. Withers. 1980. Malignant properties and DNA content of daughter clones from a mouse fibrosarcoma: differentiation between malignant properties. Br. J. Cancer 42: 765– 771. 21 Chambers, A. F., R. P. Hill & V. Ling. 1981. Tumor heterogeneity and stability of the metastatic phenotype of mouse KHT sarcoma cells. Cancer Res. 41: 1368– 1372. 22 Talmadge, J. E., J. R. Starkey & D. R. Stanford. 1981. In vitro characteristics of metastatic variant subclones of restricted genetic origin. J. Supramol. Struct. Cell Biochem. 15: 139– 151. 23 Reading, C. L., K. W. Brunson, M. Torrianni & G. L. Nicolson. 1980. Malignancies of metastatic murine lymphosarcoma cell lines and clones correlate with decreased cell surface display of RNA-tumor virus envelope glycoprotein gp70. Proc. Natl. Acad. Sci. USA 77: 5943– 5947. 24 Shearman, P. J. & B. M. Longenecker. 1981. Clonal variation and functional correlation of organ-specific metastasis and an organ-specific metastasis-associated antigen. Int. J. Cancer 27: 387– 395. 25 Enders, J. F. & G. T. Diamandopoulos. 1969. A study of variation and progression in oncogenicity in an SV 40-transformed hamster heart cell line and its clones. Proc. Roy. Soc. Ser. B 171: 431– 443. 26 Hanna, N. 1980. Expression of metastatic potential of tumor cells in young nude mice is correlated with low levels of natural killer cell-mediated cytotoxicity. Int. J. Cancer 26: 675– 680. 27 Poste, G. 1982. Experimental systems for analysis of the malignant phenotype. In Cancer Metastasis Reviews. I. J. Fidler, Ed. Nijhoff. Amsterdam . In press. 28 Fidler, I. J. & I. R. Hart. 1981. The origin of metastatic heterogeneity in tumors. Eur. J. Cancer 17: 487– 494. 29 Nowell, P. C. 1976. The clonal evolution of tumor cell populations. Acquired genetic lability permits stepwise selection of variant sublines and underlies tumor progression. Science 194: 23– 28. 30 Cifone, M. & I. J. Fidler. 1981. Increasing metastatic potential is associated with increasing genetic instability of clones isolated from murine neoplasms. Proc. Natl. Acad. Sci. USA 78: 6949– 6952. 31 Poste, G., J. Doll & I. J. Fidler. 1981. Interactions between clonal sub-populations affect the stability of the metastatic phenotype in polyclonal populations of B16 melanoma cells. Proc. Natl. Acad. Sci. USA 78: 6226– 6230. 32 Nicolson, G. L. 1981. Personal communication. 33 Poste, G., J. Tzeng, J. Doll, R. Greig & I. Zeidman. 1981. Unpublished observations. 34 Poste, G., J. Doll, A. E. Brown, J. Tzeng & I. Zeidman. 1982. A comparison of the metastatic properties of B16 melanoma clones isolated from cultured cell lines, subcutaneous tumors and individual lung tumors. Cancer Res. In press. 35 Miller, B. E., F. R. Miller, J. Leith & G. H. Heppner. 1980. Growth interaction in vivo between tumor subpopulations derived from a single mouse mammary tumor. Cancer Res. 40: 3977– 3981. 36 Newcomb, E. W., S. C. Silverstein & S. Silagi. 1978. Malignant mouse melanoma cells do not form tumors when mixed with cells of a non-malignant subclone: relationships between plasminogen activator expression by the tumor cells and the host's immune response. J. Cell Physiol. 95: 169– 177. 37 Sugarbaker, E. V. 1979. Cancer metastasis: a product of tumor-host interactions. Current Problems in Cancer III: 3– 59. Citing Literature Volume397, Issue1Cell Proliferation, Cancer, and Cancer Therapy: A Conference in Honor of Anna GoldfederDecember 1982Pages 34-48 ReferencesRelatedInformation