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Clot-strength and clot-lysis in rats fed thrombogenic diets

1962; Elsevier BV; Volume: 1; Issue: 2 Linguagem: Inglês

10.1016/0014-4800(62)90018-7

1096-0945

Kyu Taik Lee, R.F. Scott, Dong Nack Kim, Wilbur A. Thomas,

Regulation of Appetite and Obesity

Butter appears to have a different biologic effect than corn oil regarding the development of intra-arterial thrombi and infarcts in rats. Rats receiving a diet containing 40% butter (plus cholesterol, propylthiouracil, and other ingredients) develop thrombi with myocardial and renal infarcts, together with an increased clot-lysis time. If corn oil is substituted for butter no thrombi or infarcts have been found and the clot-lysis times are shorter than that of the butter-fed animals. In order to elucidate the mechanism of the thrombogenic action of butter when fed to rats, the comparative strengths of clots formed from the plasma of rats fed butter or corn oil (plus other ingredients) or a stock diet, were measured using binding power in a thrombelastograph as one index of clot-strength. In addition, clot-lysis and plasma cholesterol determinations were done on all groups. The binding powers of the clots formed from the plasma of butter- and corn oil-fed rats were not significantly different, but both fats produced clots of far greater binding power than did the low fat, stock diet. The clot-lysis times of the same butter-fed group of rats was significantly greater than that of the corn oil group. Both fat-fed groups had a longer clot-lysis time than did the stock diet group of rats. The finding of equal binding powers but different clot-lysis times in corn oil- and butter-fed rats suggests that the thrombogenic property of the 40% butter diet is due either to alterations in the lytic system secondary to the butter diet, or to aspects of clot-strength not reflected by binding power.