Artigo Acesso aberto Produção Nacional Revisado por pares

Anti-Candida activity and chemical composition of Cinnamomum zeylanicum blume essential oil

2013; Instituto de Tecnologia do Paraná (Tecpar); Volume: 56; Issue: 5 Linguagem: Inglês

10.1590/s1516-89132013000500005

ISSN

1678-4324

Autores

Ricardo Dias de Castro, Edeltrudes de Oliveira Lima,

Tópico(s)

Plant Pathogens and Fungal Diseases

Resumo

The purpose of this study was to identify the anti-Candida activity and chemical composition of the essential oil (EO) of Cinnamomum zeylanicum (cinnamon). For this, tests were conducted to determine the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) and the action of C. zeylanicum EO on fungal cell wall of Candida albicans, C. tropicalis and C. krusei strains. The composition of the was analysed by gas chromatography with mass spectrometry. Significant antifungal activity of the EO was observed on the strains tested, with 87.5% and 62.5% of them sensitive, respectively at a MIC of 312.5 µg/mL and MFC of 2500 µg/mL. In the presence of sorbitol, the MIC was 625 µg/mL against all the strains, showing a possible action of the EO on fungal cell wall. Eugenol (73.27%) and trans-β-caryophyllene (5.38%) were found in higher concentrations. The results indicated anti-Candida activity of the EO analyzed and suggested that it occurred due to the action on fungal cell wall.

Referência(s)