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Effects of acute and chronic phencyclidine on neurotransmitter enzymes in rat brain

1980; Elsevier BV; Volume: 29; Issue: 18 Linguagem: Inglês

10.1016/0006-2952(80)90361-5

1873-2968

Louise L. Hsu, Robert C. Smith, C. Rolsten, D.E. Leelavathi,

Neurotransmitter Receptor Influence on Behavior

The arylcyclohexamines are a group of psychoactive agents broadly derived from a cyclohexamine unit with an aryl moiety. The major agents in this group include phencyclidine, ketamine and methoxetamine, which expand into analogues and derivative agents. Their common shared property involves antagonism of the NMDA glutamate receptor. The chapter reviews the effects of each of the major agents by examining the latest animal and human evidence on acute and chronic toxicity from case reports, clinical studies and reported deaths. To complete the chapter, other new arylcyclohexamine agents are identified and briefly reviewed for their clinical effect and prevalence to alert the reader to their growing influence within the novel psychoactive drug scene. These structurally and pharmacodynamically similar derivates include methoxphenidine and several methoxy- analogues of phencyclidine.