Portal de Periódicos da CAPES

Tissue factor pathway inhibitor and the current concept of blood coagulation

1995; Lippincott Williams & Wilkins; Volume: 6; Issue: Sup 1 Linguagem: Inglês

10.1097/00001721-199506001-00002

1473-5733

G. J. Broze,

Coagulation, Bradykinin, Polyphosphates, and Angioedema

Tissue factor pathway inhibitor (TFPI) is a multivalent, Kunitz-type plasma proteinase inhibitor that regulates tissue factor-induced coagulation. TFPI directly inhibits activated factor X and, in a factor Xa-dependent manner, produces feedback inhibition of the factor VIIa/tissue factor catalytic complex. The properties of this inhibitor help explain the clinical need for 'extrinsic' and 'intrinsic' coagulation pathways and have led to a reformulation of the coagulation cascade. In the revised hypothesis, factor VIIa/tissue factor is responsible for the initiation of coagulation but, owing to TFPI-mediated feedback inhibition, amplification of the procoagulant response though the actions of factor VIII, IX and XI is required for sustained haemostasis.