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Nevirapine-based Antiretroviral Therapy is Associated with Lower Plasma Hepatitis C Virus Viral Load among HIV/ Hepatitis C Virus-Coinfected Patients

2010; OMICS Publishing Group; Volume: 1; Issue: 3 Linguagem: Inglês

10.4172/2155-6113.1000110

2155-6113

Rosario Mata, José Antonio López Mira, Antonio Rivero, Luís F. López‐Cortés, Manuel Torres- Tortosa,

HIV/AIDS drug development and treatment

Patients and MethodsAll HIV/HCV-coinfected patients who received peg-IFN plus RBV along with a PI-or NNRTI-based ART at thirteen hospitals in Spain from January 2004 to December 2008, were included in this retrospective cross-sectional study.Measurements of plasma HCV-RNA load were performed at baseline, before starting peg-IFN plus RBV, using a comercial PCR assay (Cobas Taqman; Roche Diagnostic Systems Inc., Pleasanton, CA, USA: detection limit of 50 IU/mL).The Kruskal-Wallis test and the Chi-square test for RxC tables were used to compare continuous variables and categorical variables, respectively.Posthoc comparisons between groups were carried out using the Mann-Whitnney U test and the Chi-square test for tables 2x2.Associations with a p value <0.05 were considered significant for comparisons among groups.The correction of Bonferroni was applied for the comparisons between groups in the post-hoc analysis.For these comparisons a p value <0.016 was considered significant.The Pearson r coefficient was used to examine the correlation between the levels of HCV viremia and the length of exposure to NVP-EFV-or PIs and the time with undetectable HIV viral load.