Regulation of macrophage activation and inflammation by spermine: A new chapter in an old story
2000; Lippincott Williams & Wilkins; Volume: 28; Issue: Supplement Linguagem: Inglês
10.1097/00003246-200004001-00007
ISSN1530-0293
AutoresMinghuang Zhang, Haichao Wang, Kevin J. Tracey,
Tópico(s)Sex work and related issues
ResumoSpermine, a naturally occurring polyamine, is a ubiquitous structural component of all eukaryotic cells. Regenerating tissues produce higher levels of spermine, and injured or dying cells release spermine into the extracellular milieu, so that tissue levels increase significantly at inflammatory sites of infection or injury. Recent research has focused on delineating the significance of spermine accumulation in the inflammatory process. The discovery that spermine is a negative regulator of macrophage activation provided a mechanism by which spermine influences the biology of inflammation. Mechanistic studies indicate that spermine is incorporated into macrophages and restrains the innate immune response. This anti-inflammatory process is facilitated by the negative acute-phase protein, fetuin.
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