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Smoking is associated with mosaic loss of chromosome Y

2014; American Association for the Advancement of Science; Volume: 347; Issue: 6217 Linguagem: Inglês

10.1126/science.1262092

1095-9203

Jan P. Dumanski, Chiara Rasi, Mikael Lönn, Hanna Davies, Martin Ingelsson, Vilmantas Giedraitis, Lars Lannfelt, Patrik K. E. Magnusson, Cecilia M. Lindgren, Andrew P. Morris, David Cesarini, Magnus Johannesson, Eva Tiensuu Janson, Lars Lind, Nancy L. Pedersen, Erik Ingelsson, Lars A. Forsberg,

Carcinogens and Genotoxicity Assessment

Men beware, when smoke gets in your Y's The relationship between tobacco smoking and elevated cancer risk has been recognized for 60 years. Yet what smoking does to our genetic material is still not fully understood. New work suggests that men should be particularly concerned. In a study of over 6000 men, Dumanski et al. find that men who smoke are more than three times as likely as nonsmokers to show loss of the Y chromosome in their blood cells. Whether this is a causal factor in cancer development or simply a marker of more consequential damage on other chromosomes could not be deduced from the study. Science , this issue p. 81