Structural analysis of five new monosialylated oligosaccharides from human milk
1992; Elsevier BV; Volume: 296; Issue: 2 Linguagem: Inglês
10.1016/0003-9861(92)90616-5
ISSN1096-0384
AutoresGunnar Grönberg, Peter Lipniunas, Torgny Lundgren, Frank Lindh, Bo Nilsson,
Tópico(s)Breastfeeding Practices and Influences
ResumoThe total monosialylated oligosaccharide fraction from pooled human milk was isolated by gel filtration and ion-exchange chromatography. Further separation by HPLC using a mobile phase containing an ion-pairing reagent of triethylamine gave five new monosialylated oligosaccharides. Structural analysis was carried out by chemical analyses, fast atom bombardment mass spectrometry, and 500-MHz NMR spectroscopy. Combined structural data revealed the following new structures: [formula: see text]
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