Portal de Periódicos da CAPES

Nor-Seco-Cucurbit[10]uril Exhibits Homotropic Allosterism

2006; American Chemical Society; Volume: 128; Issue: 46 Linguagem: Inglês

10.1021/ja064776x

1943-2984

Wei‐Hao Huang, Simin Liu, Peter Y. Zavalij, Lyle Isaacs,

Crystallography and molecular interactions

The condensation of glycoluril and formaldehyde in concentrated HCl at 50 degrees C delivers nor-seco-cucurbit[10]uril (ns-CB [10]). 1H NMR and X-ray crystallographic evidence indicates that the two cavities of ns-CB[10] accommodate guests that are typically bound within CB[6] or CB[7]. Several interesting types of selectivity are possible within these ternary complexes-top/center isomerism, diastereoselective complexation of chiral (but racemic) guest pairs, and guest size controlled homotropic allosterism.