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Adolescent Obesity and Paternal Country of Origin Predict Renal Cell Carcinoma: A Cohort Study of 1.1 Million 16 to 19-Year-Old Males

2012; Lippincott Williams & Wilkins; Volume: 189; Issue: 1 Linguagem: Inglês

10.1016/j.juro.2012.08.184

1527-3792

Adi Leiba, Jeremy D. Kark, Arnon Afek, Estela Derazne, Micha Barchana, Dorit Tzur, Asaf Vivante, Ari Shamiss,

Multiple and Secondary Primary Cancers

No AccessJournal of UrologyAdult Urology1 Jan 2013Adolescent Obesity and Paternal Country of Origin Predict Renal Cell Carcinoma: A Cohort Study of 1.1 Million 16 to 19-Year-Old Males Adi Leiba, Jeremy D. Kark, Arnon Afek, Estela Derazne, Micha Barchana, Dorit Tzur, Asaf Vivante, and Ari Shamiss Adi LeibaAdi Leiba Nephrology and Hypertension Institute, Tel Hashomer, Israel Sheba Medical Center and Medical Corps, Israeli Defense Forces, Tel Hashomer, Israel Mount Auburn Hospital, Department of Medicine, Harvard Medical School, Cambridge, Massachusetts , Jeremy D. KarkJeremy D. Kark Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel , Arnon AfekArnon Afek Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel , Estela DerazneEstela Derazne Sheba Medical Center and Medical Corps, Israeli Defense Forces, Tel Hashomer, Israel , Micha BarchanaMicha Barchana The National Cancer Registry, Ministry of Health, Jerusalem, Israel , Dorit TzurDorit Tzur Sheba Medical Center and Medical Corps, Israeli Defense Forces, Tel Hashomer, Israel , Asaf VivanteAsaf Vivante Talpiot Medical Leadership Program, Edmond and Lily Safra Children's Hospital, Tel Hashomer, Israel Sheba Medical Center and Medical Corps, Israeli Defense Forces, Tel Hashomer, Israel , and Ari ShamissAri Shamiss Sheba Medical Center and Medical Corps, Israeli Defense Forces, Tel Hashomer, Israel Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel View All Author Informationhttps://doi.org/10.1016/j.juro.2012.08.184AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The incidence of renal cell carcinoma has increased in recent decades, particularly among middle-aged adults. Early precursors of renal cancer remain unclear. We evaluated the association of body mass index and height determined in late adolescence, and paternal or grandpaternal country of origin with the risk of renal cell carcinoma. Materials and Methods: Health related data on 1,110,835 males at ages 16 to 19 years who were examined for fitness for military service between 1967 and 2005 were linked to the Israel National Cancer Registry in this nationwide, population based cohort study. We used Cox proportional hazards modeling to estimate the HR of renal cell carcinoma associated with birth year, body mass index, height, father country of origin and socioeconomic indicators. Results: During 19,576,635 person-years of followup renal cancer developed in 274 examinees. Substantial excess risk was conferred by a body mass index of greater than 27.5 kg/m2 compared to less than 22.5 kg/m2 (HR 2.43, 95% CI 1.54–3.83, p <0.0001). Asian or African origin was protective compared to European origin (African origin HR 0.67, 95% CI 0.49–0.92). Conclusions: Overweight in late adolescence is a substantial risk factor for renal cell carcinoma. European origin is independently associated with excess risk and it persists among Israeli born males. Preventing childhood obesity may be a promising target for decreasing the burden of renal cancer. References 1 : Epidemiology of renal cell cancer. Hematol Oncol Clin N Am2011; 25: 651. Google Scholar 2 : Contemporary epidemiology of renal cell cancer. Cancer J2008; 14: 288. Google Scholar 3 : Body mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet2008; 371: 569. Google Scholar 4 : Body mass index, physical activity, and risk of renal cell carcinoma. Int J Obes (London)2006; 30: 940. Google Scholar 5 : Type 2 diabetes and the risk of renal cell cancer in women. Diabetes Care2011; 34: 1552. 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Google Scholar © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byLaguna M (2020) Re: Effect of Obesity and Overweight Status on Complications and Survival after Minimally Invasive Kidney Surgery in Patients with Clinical T2-4 Renal MassesJournal of Urology, VOL. 204, NO. 2, (383-384), Online publication date: 1-Aug-2020.Laguna M (2015) Re: International Variations and Trends in Renal Cell Carcinoma Incidence and MortalityJournal of Urology, VOL. 194, NO. 4, (950-951), Online publication date: 1-Oct-2015.Laguna M (2013) Re: Practice-Setting and Surgeon Characteristics Heavily Influence the Decision to Perform Partial Nephrectomy among American Urologic Association SurgeonsJournal of Urology, VOL. 190, NO. 3, (864-864), Online publication date: 1-Sep-2013. Volume 189Issue 1January 2013Page: 25-29 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.Keywordsobesitykidneyethnic groupscarcinoma, renal celladolescentMetricsAuthor Information Adi Leiba Nephrology and Hypertension Institute, Tel Hashomer, Israel Sheba Medical Center and Medical Corps, Israeli Defense Forces, Tel Hashomer, Israel Mount Auburn Hospital, Department of Medicine, Harvard Medical School, Cambridge, Massachusetts More articles by this author Jeremy D. Kark Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel More articles by this author Arnon Afek Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel More articles by this author Estela Derazne Sheba Medical Center and Medical Corps, Israeli Defense Forces, Tel Hashomer, Israel More articles by this author Micha Barchana The National Cancer Registry, Ministry of Health, Jerusalem, Israel More articles by this author Dorit Tzur Sheba Medical Center and Medical Corps, Israeli Defense Forces, Tel Hashomer, Israel More articles by this author Asaf Vivante Talpiot Medical Leadership Program, Edmond and Lily Safra Children's Hospital, Tel Hashomer, Israel Sheba Medical Center and Medical Corps, Israeli Defense Forces, Tel Hashomer, Israel More articles by this author Ari Shamiss Sheba Medical Center and Medical Corps, Israeli Defense Forces, Tel Hashomer, Israel Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel More articles by this author Expand All Advertisement PDF downloadLoading ...