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BIBTEX RIS

Anti-NMDA receptor encephalitis, autoimmunity, and psychosis

2014; Elsevier BV; Volume: 176; Issue: 1 Linguagem: Inglês

10.1016/j.schres.2014.10.007

ISSN

1573-2509

Autores

Matthew S. Kayser, Josep Dalmau,

Tópico(s)

Genetics and Neurodevelopmental Disorders

Resumo

Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is a recently-discovered synaptic autoimmune disorder in which auto-antibodies target NMDARs in the brain, leading to their removal from the synapse. Patients manifest with prominent psychiatric symptoms – and in particular psychosis – early in the disease course. This presentation converges with long-standing evidence on multiple fronts supporting the glutamatergic model of schizophrenia. We review mechanisms underlying disease in anti-NMDAR encephalitis, and discuss its role in furthering our understanding of neural circuit dysfunction in schizophrenia.

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