The polycythaemia rubra vera‐1 gene is constitutively expressed by bone marrow cells and does not discriminate polycythaemia vera from reactive and other chronic myeloproliferative disorders
2003; Wiley; Volume: 123; Issue: 3 Linguagem: Inglês
10.1046/j.1365-2141.2003.04641.x
ISSN1365-2141
AutoresOliver Bock, Ebru Serinsöz, Michael Neusch, Jérôme Schlué, Hans Kreipe,
Tópico(s)Acute Myeloid Leukemia Research
ResumoLittle is known about the expression of the polycythaemia rubra vera-1 (PRV-1) gene in bone marrow cells. To determine the expression level of PRV-1 in the bone marrow, we analysed PRV-1 quantitatively in Polycythaemia vera, other chronic myeloproliferative disorders, and reactive states. We demonstrated that PRV-1 was constitutively expressed in both myeloproliferative and reactive states. We concluded that, rather than an upregulation of the PRV-1 gene in the clonal haematopoiesis of polycythaemia vera, a failure to downregulate PRV-1 in granulocytes emigrating from the bone marrow might be responsible for the increase of transcripts in peripheral cells.
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