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Revisão Revisado por pares
BIBTEX RIS

The Tumor Suppressor Protein p16INK4a

1997; Elsevier BV; Volume: 237; Issue: 1 Linguagem: Inglês

10.1006/excr.1997.3824

ISSN

1090-2422

Autores

Manuel Serrano,

Tópico(s)

Ubiquitin and proteasome pathways

Resumo

The tumor suppressor protein p16INK4a(inhibitor of CDK4) is one of the most direct links between cell-cycle control and cancer. The p16INK4agene is frequently inactivated in human tumors, and inheritance of mutant alleles results in susceptibility to several types of cancer. p16INK4ais part of a cell-cycle regulatory pathway that converges in the tumor suppressor protein Rb. The mechanisms that regulate p16INK4aare starting to be characterized.

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