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Electrographic Evidence of Impaired Brain Function in Chronically Anxious Patients

1960; American Association for the Advancement of Science; Volume: 131; Issue: 3414 Linguagem: Inglês

10.1126/science.131.3414.1671

1095-9203

Charles E. Wells, Harold G. Wolff,

Functional Brain Connectivity Studies

In a study of cerebral function by electroencephalographic techniques the following observations have been made. (i) In intact subjects, repeated stimulation with bright light causes a predictable change (alpha blocking) in the electroencephalogram, whereas repeated auditory stimulation does not. (ii) If, however, an auditory stimulus is presented repeatedly just before the visual stimulus, the sound temporarily but predictably acquires the property of the light to suppress the alpha activity. (iii) This linkage between sound and light occurs much less frequently in human subjects with known amounts of structural brain damage. (iv) A similar electrophysiological defect, implying impairment of brain function, occurs in patients showing severe anxiety during prolonged periods of difficulty in over-all adaptation.