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Structure of the respiratory NADH:ubiquinone oxidoreductase (complex I)

1999; Elsevier BV; Volume: 9; Issue: 4 Linguagem: Inglês

10.1016/s0959-440x(99)80067-0

1879-033X

Nikolaus Grigorieff,

Mitochondrial Function and Pathology

Three-dimensional structures of NADH:ubiquinone oxidoreductase (or complex I) from the respiratory chain of mitochondria and bacteria have been recently studied by electron microscopy. The low-resolution structures all reveal a characteristic L shape for complex I; however, some of the differences among these structures may have important implications for the location of the functional elements of complex I, for example, the ubiquinone-binding site.