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BIBTEX RIS

Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure

2008; Oxford University Press; Volume: 80; Issue: 3 Linguagem: Inglês

10.1093/cvr/cvn215

ISSN

1755-3245

Autores

Pasquale Gallo, Michael V.G. Latronico, Paolo Gallo, Séréna Grimaldi, Francesco Borgia, Matilde Todaro, Philip Jones, Paola Gallinari, Raffaele De Francesco, Gennaro Ciliberto, Christian Steinkühler, Giovanni Esposito, Gianluigi Condorelli,

Tópico(s)

Protein Degradation and Inhibitors

Resumo

AimsRecent studies have demonstrated the importance of chromatin remodelling via histone acetylation/deacetylation for the control of cardiac gene expression. Specific histone deacetylases (HDACs) can, in fact, play a positive or negative role in determining cardiac myocyte (CM) size. Here, we report on the effect on hypertrophy development of three inhibitors (HDACi) of class I HDACs.

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