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“Biogenic” aldehyde metabolism relation to pentose shunt activity in brain

1974; Elsevier BV; Volume: 23; Issue: 12 Linguagem: Inglês

10.1016/0006-2952(74)90398-0

1873-2968

Boris Tabakoff, William R. Groskopf, Robert Anderson, Spyridon G.A. Alivisatos,

Photoreceptor and optogenetics research

Biogenic amines, added to brain homogenates, were demonstrated to stimulate oxidative decarboxylation of glucose isotopically labeled at C-1. This effect was ascribed to the stimulation of the pentose phosphate shunt in brain and was found to depend on the monoamine oxidase (MAO)-catalyzed production of the aldehyde derivatives (biogenic aldehydes) of the biogenic amines. The stimulation produced by the amines and the aldehydes was shown to be inhibited by barbiturates, and the enzymes responsible for the stimulated metabolism of glucose were found to be present in the cytosol. Evidence is presented indicating that the stimulation produced by biogenic aldehydes depends on the oxidation of NADPH to NADP by aldehyde reductase present in brain cytosol. Acid derivatives of the biogenic amines [i.e. 5-hydroxyindoleacetic acid (5-HIAA)]were found to inhibit aldehyde-stimulated metabolism of glucose by the pentose phosphate shunt.