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Rapid prototyped PGA/PLA scaffolds in the reconstruction of mandibular condyle bone defects

2009; Wiley; Volume: 6; Issue: 1 Linguagem: Inglês

10.1002/rcs.290

1478-596X

Hua Xu, Dong Han, Jia‐Sheng Dong, Guo‐Xiong Shen, Gang Chai, Zheyuan Yu, Wei‐Jun Lang, Songtao Ai,

Dental Implant Techniques and Outcomes

Abstract Background Craniomaxillofacial bone defects are currently reconstructed by using computer‐aided design and manufacturing (CAD/CAM) processes. We have developed a novel digital medical support system that enables us to custom‐make scaffolds to repair craniomaxillofacial bone defects using three‐dimensional computed tomographic (CT) images and a rapid‐prototyping method. Methods We created positive molds using CT data, CAD/CAM and a rapid prototyping method using 3D printing. Custom‐made poly (glycolic acid) (PGA) and polymers poly (lactic acid) (PLA) scaffolds were prefabricated by a positive‐negative mold interchange technique. A laser scanning system was used to evaluate the accuracy of the PGA/PLA scaffold. Bone marrow stem cells were incubated with the scaffold to assess biocompatibility. Results The mean error was <0.3 mm and confidence was ≥95% when the error was <1 mm. Results from in vitro cell culture demonstrated that the PGA/PLA scaffold had excellent cellular compatibility. Conclusions This pilot study suggests that custom‐made PGA/PLA scaffolds infiltrated with bone marrow stem cells may be effective for future treatment of craniomaxillofacial bone injuries. Copyright © 2009 John Wiley & Sons, Ltd.