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Identification of Risk Factors for Chronic Q Fever, the Netherlands

2012; Centers for Disease Control and Prevention; Volume: 18; Issue: 4 Linguagem: Inglês

10.3201/eid1804.111478

1080-6059

Linda M. Kampschreur, Sandra Dekker, Julia C.J.P. Hagenaars, P Lestrade, Nicole H. M. Renders, Monique G.L. de Jager-Leclercq, Mirjam H. A. Hermans, Cornelis A. R. Groot, Rolf H. H. Groenwold, Andy I. M. Hoepelman, Peter C. Wever, Jan Jelrik Oosterheert,

Rabies epidemiology and control

Abstract Since 2007, the Netherlands has experienced a large Q fever outbreak. To identify and quantify risk factors for development of chronic Q fever after Coxiella burnetii infection, we performed a case–control study. Comorbidity, cardiovascular risk factors, medications, and demographic characteristics from 105 patients with proven (n = 44), probable (n = 28), or possible (n = 33) chronic Q fever were compared with 201 patients who had acute Q fever in 2009 but in whom chronic Q fever did not develop (controls). Independent risk factors for development of proven chronic Q fever were valvular surgery, vascular prosthesis, aneurysm, renal insufficiency, and older age.