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Toxicological evaluation of neem (Azadirachta indica) oil: Acute and subacute toxicity

2013; Elsevier BV; Volume: 35; Issue: 2 Linguagem: Inglês

10.1016/j.etap.2012.12.015

1872-7077

Yunxia Deng, Mei Cao, Dongxia Shi, Zhongqiong Yin, Renyong Jia, Jiao Xu, Chuan Wang, Cheng Lv, Xiaoxia Liang, Quan‐Bin Han, Zhirong Yang, Jian Zhao,

Pesticide Exposure and Toxicity

Neem (Azadirachta indica), popularly known as traditional medicine is a native plant in India. Neem oil is a vegetable oil derived from seeds or fruits of the neem tree through pressing or solvent extraction, and largely used in popular medicine to have antifungal, antibacterial, antimalarial, antiparasitic, anti-inflammatory, as well as immunemodulatory properties in different animal species. In the present study, acute and 28-day subacute toxicity tests were carried out. In the acute toxicity test, the LD50 values of neem oil were found to be 31.95 g/kg. The subacute treatment with neem oil failed to change body weight gain, food and water consumption. Serum biochemistry analysis showed no significant differences in any of the parameters examined under the dose of 1600 mg/kg/day. Histopathological exams showed that the target organs of neem oil were testicle, liver and kidneys up to the dose of 1600 mg/kg/day.