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Constitutive Activation of PKA Catalytic Subunit in Adrenal Cushing's Syndrome

2014; Massachusetts Medical Society; Volume: 370; Issue: 11 Linguagem: Inglês

10.1056/nejmoa1310359

1533-4406

Felix Beuschlein, Martin Faßnacht, Guillaume Assié, Davide Calebiro, Constantine A. Stratakis, Andrea Oßwald, Cristina L. Ronchi, Thomas Wieland, Silviu Sbiera, Fábio R. Faucz, Katrin Schaak, Anett Schmittfull, Thomas Schwarzmayr, Olivia Barreau, Delphine Vezzosi, Marthe Rizk‐Rabin, Ulrike Zabel, Eva Szarek, Calvin Ke, Antonella Forlino, Annalisa Vetro, Orsetta Zuffardi, Caroline Kisker, Susanne Diener, Thomas Meitinger, Martin J. Lohse, Martín Reincke, Jérôme Bertherat, Tim M. Strom, Bruno Allolio,

Cancer, Hypoxia, and Metabolism

Corticotropin-independent Cushing's syndrome is caused by tumors or hyperplasia of the adrenal cortex. The molecular pathogenesis of cortisol-producing adrenal adenomas is not well understood.