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Integrative approaches for finding modular structure in biological networks

2013; Nature Portfolio; Volume: 14; Issue: 10 Linguagem: Inglês

10.1038/nrg3552

1471-0064

Koyel Mitra, Anne‐Ruxandra Carvunis, Sanath Kumar Ramesh, Trey Ideker,

Computational Drug Discovery Methods

A central goal of systems biology is to elucidate the structural and functional architecture of the cell. To this end, large and complex networks of molecular interactions are being rapidly generated for humans and model organisms. A recent focus of bioinformatics research has been to integrate these networks with each other and with diverse molecular profiles to identify sets of molecules and interactions that participate in a common biological function - that is, 'modules'. Here, we classify such integrative approaches into four broad categories, describe their bioinformatic principles and review their applications.