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Thrombotic Microangiopathy with Renal Failure in Two Patients Undergoing Gemcitabine Chemotherapy

1999; Karger Publishers; Volume: 19; Issue: 5 Linguagem: Inglês

10.1159/000013525

1421-9670

Karl Lhotta, Thomas Kühr, Hans J. Rumpelt, Ewald Wöll, Josef Thaler, Paul König,

Renal Diseases and Glomerulopathies

Described here are 2 patients who developed thrombotic microangiopathy of the kidneys after receiving high cumulative doses of the new anticancer drug gemcitabine. The first patient, who received gemcitabine for treatment of a carcinoma of the pancreas, required hemodialysis for 6 months. In the second case, a woman suffering from a cholangiocellular carcinoma, end-stage renal disease was irreversible. Clinical awareness, timely detection and discontinuation of gemcitabine are mandatory to prevent this rare but disastrous complication of gemcitabine therapy.