Genetic susceptibility and anti-human platelet antigen 5b alloimmunization role of HLA class II and TAP genes
1996; Elsevier BV; Volume: 46; Issue: 2 Linguagem: Inglês
10.1016/0198-8859(96)00019-5
ISSN1879-1166
AutoresG. Sémana, Thierry Zazoun, Mehdi Alizadeh, Marie‐Christine Morel‐Kopp, B Genetet, Cécile Kaplan,
Tópico(s)Immunodeficiency and Autoimmune Disorders
ResumoPlatelet alloimmunization may result in post-transfusion purpura, and during pregnancy may cause neonatal alloimmune thrombocytopenia (NAIT), with a frequency estimated at 1.3 per 1000 live births. The risk of morbidity is significant: 20% of affected infants have neurologic sequelae and the death rate is about 10%. A better understanding of the immune response to platelet alloantigens would allow for a better definition, and thus better management of pregnant women at high risk. Limited data are available on the immune response against HPA-5b, the second most frequent antigen, after HPA-1a, implicated in NAIT. We studied HLA class II and TAP gene polymorphism in 50 women immunized against HPA-5 system antigens. Our results suggest a strong association of alloimmunization with a cluster of HLA DR molecules sharing a particular polymorphic amino acid sequence at position 69-70 (Glu-Asp encoded by GAA-GAC nucleotide sequence) of the DR beta 1 chain (RR = 2.95, RR = 5.70 when patients were homozygous for this sequence), and a negative association with the DRB1*0301 allele (2.1% vs. 28%; RR = 0.08). Furthermore, increased frequency of a TAP2 dimorphism at position 379 was observed in immunized women against the HPA-5 antigens (RR = 4.7).
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