Central Acute D2 Stimulation Worsens Bladder Function in Patients With Mild Parkinson’s Disease
2005; Lippincott Williams & Wilkins; Volume: 175; Issue: 1 Linguagem: Inglês
10.1016/s0022-5347(05)00058-3
ISSN1527-3792
AutoresLivia Brusa, Filomena Petta, Antonio Pisani, Roberto Miano, Paolo Stanzione, Vincenzo Moschella, Salvatore Galati, Enrico Finazzi Agrò,
Tópico(s)Neurological disorders and treatments
ResumoNo AccessJournal of UrologyAdult urology1 Jan 2006Central Acute D2 Stimulation Worsens Bladder Function in Patients With Mild Parkinson's Disease Livia Brusa, Filomena Petta, Antonio Pisani, Roberto Miano, Paolo Stanzione, Vincenzo Moschella, Salvatore Galati, and Enrico Finazzi Agrò Livia BrusaLivia Brusa Department of Neurology, University of Rome Tor Vergata, Rome, Italy Department of I.R.C.C.S. Fondazione S. Lucia, Rome, Italy , Filomena PettaFilomena Petta Department of Urology, University of Rome Tor Vergata, Rome, Italy , Antonio PisaniAntonio Pisani Department of Neurology, University of Rome Tor Vergata, Rome, Italy Department of I.R.C.C.S. Fondazione S. Lucia, Rome, Italy , Roberto MianoRoberto Miano Department of Urology, University of Rome Tor Vergata, Rome, Italy , Paolo StanzionePaolo Stanzione Department of Neurology, University of Rome Tor Vergata, Rome, Italy Department of I.R.C.C.S. Fondazione S. Lucia, Rome, Italy , Vincenzo MoschellaVincenzo Moschella Department of Neurology, University of Rome Tor Vergata, Rome, Italy , Salvatore GalatiSalvatore Galati Department of Neurology, University of Rome Tor Vergata, Rome, Italy , and Enrico Finazzi AgròEnrico Finazzi Agrò Department of Urology, University of Rome Tor Vergata, Rome, Italy Department of I.R.C.C.S. Fondazione S. Lucia, Rome, Italy View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)00058-3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The different roles of D1 and D2 dopamine receptors in LUT behavior have been demonstrated in animal studies. In particular D2 selective agonists and D1 selective antagonists seem to produce a reduction of the bladder capacity in conscious rats. This finding has never been confirmed in human studies. Thus, in this study we investigated the role of D1 and D2 agonists/antagonists on LUT behavior in patients with PD. Materials and Methods: A total of 87 patients with mild PD were evaluated. Patients were evaluated with urodynamic studies (cystometry followed by a pressure flow study with perineal floor electromyography) performed in off status and after oral administration of 250 mg of LD. In 70 patients a third urodynamic evaluation was conducted in one of the following conditions: after simultaneous administration of 250 mg oral LD and 60 or 120 mg oral domperidone (D2 peripheral antagonist); after simultaneous administration of 250 mg oral LD and 25, 50 or 150 mg intramuscular L-sulpiride (D2 central and peripheral antagonist). Several urodynamic parameters were evaluated and results obtained in different conditions compared. Results: LD alone worsened detrusor overactivity: in particular, a reduction of first urinary sensation, involuntary detrusor contraction threshold (reflex volume) and bladder capacity was observed. L-sulpiride (central and peripheral D2 antagonist) coadministration counteracted the worsening in a dose dependent manner. Domperidone (peripheral D2 antagonist) coadministration failed to determine the same counteraction. Conclusions: According to our results, a central acute D2 stimulation seems to be responsible of a reduction of bladder capacity with worsening of detrusor overactivity in patients with mild PD. References 1 : Voiding dysfunction in Parkinson's disease. Jpn J Psychiatry Neurol1992; 46: 181. Google Scholar 2 : Neurourologic findings in Parkinson's disease. J Urol1983; 129: 80. Link, Google Scholar 3 : Effect of apomorphine and L-dopa on the parkinsonian bladder. Neurourol Urodyn1993; 12: 203. 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Google Scholar © 2006 by American Urological AssociationFiguresReferencesRelatedDetailsCited ByKitta T, Chancellor M, de Groat W, Kuno S, Nonomura K and Yoshimura N (2018) Suppression of Bladder Overactivity by Adenosine A2A Receptor Antagonist in a Rat Model of Parkinson DiseaseJournal of Urology, VOL. 187, NO. 5, (1890-1897), Online publication date: 1-May-2012. Volume 175Issue 1January 2006Page: 202-206 Advertisement Copyright & Permissions© 2006 by American Urological AssociationKeywordsparkinson diseasereceptorsurodynamicsdopamineMetricsAuthor Information Livia Brusa Department of Neurology, University of Rome Tor Vergata, Rome, Italy Department of I.R.C.C.S. Fondazione S. Lucia, Rome, Italy More articles by this author Filomena Petta Department of Urology, University of Rome Tor Vergata, Rome, Italy More articles by this author Antonio Pisani Department of Neurology, University of Rome Tor Vergata, Rome, Italy Department of I.R.C.C.S. Fondazione S. Lucia, Rome, Italy More articles by this author Roberto Miano Department of Urology, University of Rome Tor Vergata, Rome, Italy More articles by this author Paolo Stanzione Department of Neurology, University of Rome Tor Vergata, Rome, Italy Department of I.R.C.C.S. Fondazione S. Lucia, Rome, Italy More articles by this author Vincenzo Moschella Department of Neurology, University of Rome Tor Vergata, Rome, Italy More articles by this author Salvatore Galati Department of Neurology, University of Rome Tor Vergata, Rome, Italy More articles by this author Enrico Finazzi Agrò Department of Urology, University of Rome Tor Vergata, Rome, Italy Department of I.R.C.C.S. Fondazione S. Lucia, Rome, Italy More articles by this author Expand All Advertisement PDF DownloadLoading ...
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