Asymmetric epoxidation of allylic alcohol by the modified sharpless reagent
1987; Elsevier BV; Volume: 43; Issue: 13 Linguagem: Inglês
10.1016/s0040-4020(01)86832-0
ISSN1464-5416
Autores Tópico(s)Organic Chemistry Cycloaddition Reactions
ResumoThe modified Sharpless reagent can be applied to the epoxidation of various allylic alcohols just as the Sharpless reagent does, but the reaction time was greatly reduced. Methyl gibberellate 10, which failed to give the normal epoxidation product on treatment with Sharpless reagent, readily yielded the corresponding epoxy derivative 22 when the modified Sharpless reagent was used.
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