Autonomic Nervous Function in Huntington's Disease
1988; American Medical Association; Volume: 45; Issue: 3 Linguagem: Inglês
10.1001/archneur.1988.00520270087025
ISSN1538-3687
AutoresJan C. den Heijer, Ward L. E. M. Bollen, J. P. H. Reulen, J. Gert van Dijk, C.G.S. Kramer, R. A. C. Roos, O. J. S. Buruma,
Tópico(s)Neurological disorders and treatments
Resumo• Autonomic nervous system function was studied by means of a series of standardized tests in 11 patients with Huntington's disease (HD) and in 11 ageand sex-matched controls. Two statistically significant differences were found. The blood pressure response to sustained handgrip was diminished and the pupillary light reflex latency was increased in the HD group. The former probably reflects diminished input from higher centers on an otherwise intact sympathetic nervous system. The latter may indicate involvement of the pretectal or Edinger-Westphal nuclei in HD. No further signs of autonomic nervous system dysfunction were found.
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