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Effects of 4 Classes of Cardiovascular Drugs on Ventricular Function in Dogs with Mitral Regurgitation

2007; Wiley; Volume: 21; Issue: 3 Linguagem: Inglês

10.1892/0891-6640(2007)21[445

1939-1676

Tomohiro Nakayama, Yoshinori Nishijima, Mutsumi Miyamoto, Robert L. Hamlin,

Heart Failure Treatment and Management

Journal of Veterinary Internal MedicineVolume 21, Issue 3 p. 445-450 Open Access Effects of 4 Classes of Cardiovascular Drugs on Ventricular Function in Dogs with Mitral Regurgitation Tomohiro Nakayama, Tomohiro Nakayama Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.Search for more papers by this authorYoshinori Nishijima, Yoshinori Nishijima Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.Search for more papers by this authorMutsumi Miyamoto, Mutsumi Miyamoto Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.Search for more papers by this authorRobert L. Hamlin, Robert L. Hamlin Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210. Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1900 Coffey Road, Columbus, OH43210; e-mail: [email protected].Search for more papers by this author Tomohiro Nakayama, Tomohiro Nakayama Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.Search for more papers by this authorYoshinori Nishijima, Yoshinori Nishijima Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.Search for more papers by this authorMutsumi Miyamoto, Mutsumi Miyamoto Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.Search for more papers by this authorRobert L. Hamlin, Robert L. Hamlin Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210. Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1900 Coffey Road, Columbus, OH43210; e-mail: [email protected].Search for more papers by this author First published: 05 February 2008 https://doi.org/10.1111/j.1939-1676.2007.tb02988.xCitations: 12 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Background:There have been few trials in which dogs with mitral regurgitation (MR) have been treated with various cardioactive drugs to determine effects on left ventricular (LV) function. Hypothesis:Four classes of cardiovascular drugs may improve LV function in dogs with MR without increasing MR. Animals:Nine mature dogs were included in the study. Methods:MR was produced in 9 dogs. Five months later under butorphanol narcosis, parameters of LV function and left atrial dimension (LAD) were monitored by LV micromanometry and echocardiography/Doppler. Dogs were given (in random order) enalaprilat, nitroglycerine, ouabain, milrinone, and placebo. Results:Nitroglycerin produced no significant change; milrinone and ouabain increased contractility; ouabain decreased heart rate; and there was evidence that enalaprilat and milrinone decreased LAD. Milrinone and ouabain decreased isovolumetric contraction time and therefore the time available for MR. There was no evidence that a positive inotrope increased MR despite increasing LV contractility and stroke volume. Conclusion and Clinical Importance: This study contradicts the hypotheses that (1) strengthening the left ventricle may increase MR and (2) treatment of MR (even before symptoms of heart failure develop) may decrease LAD. It is reasonable that strengthening the force of LV contraction should increase the driving pressure for MR; however, this effect did not appear to increase MR. Although some investigators believe that treating dogs with MR with afterload reducers and decreasing hindrance to ejection of blood from the LV to aorta may lengthen life by decreasing MR, there did not appear to be a reduction in MR, at least in response to the angiotensin-converting enzyme (ACE) inhibitor. References 1 Sellers R., Levy M., Amplatz K., Lillehei CW. 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