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A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry

2013; Nature Portfolio; Volume: 45; Issue: 6 Linguagem: Inglês

10.1038/ng.2608

1546-1718

Keri L. Monda, Gary K. Chen, Kira C. Taylor, Cameron D. Palmer, Todd L. Edwards, Leslie A. Lange, Maggie C. Y. Ng, Adebowale Adeyemo, Matthew Allison, Lawrence F. Bielak, Guanjie Chen, Mariaelisa Graff, Marguerite R. Irvin, Suhn K. Rhie, Li Guo, Yongmei Liu, Youfang Liu, Yingchang Lu, Michael A. Nalls, Yan V. Sun, Mary K. Wojczynski, Lisa R. Yanek, Melinda C. Aldrich, Adeyinka Ademola, Christopher I. Amos, Elisa V. Bandera, Cathryn H. Bock, Angela Britton, Ulrich Broeckel, Quiyin Cai, Neil E. Caporaso, Chris Carlson, John Carpten, Graham Casey, Wei‐Min Chen, Fang Chen, Yii-Der I. Chen, Charleston W. K. Chiang, Gerhard A. Coetzee, Ellen W. Demerath, Sandra Deming-Halverson, Ryan W Driver, Patricia M. Dubbert, Mary F. Feitosa, Ye Feng, Barry I. Freedman, Elizabeth M. Gillanders, Omri Gottesman, Xiuqing Guo, Talin Haritunians, Tamara Harris, Curtis C. Harris, Anselm Hennis, Dena Hernández, Lorna H. McNeill, Timothy D. Howard, Barbara V. Howard, Virginia J. Howard, Karen Johnson, Sun Jung Kang, Brendan J. Keating, Suzanne Kolb, Lewis H. Kuller, Abdullah Kutlar, Carl D. Langefeld, Guillaume Lettre, Kurt Lohman, Vaneet Lotay, Helen N. Lyon, JoAnn E. Manson, William Maixner, Yan Meng, Kristine R. Monroe, Imran Morhason‐Bello, Adam B. Murphy, Josyf C. Mychaleckyj, Rajiv Nadukuru, Katherine L. Nathanson, Uma Nayak, Amidou N’Diaye, Barbara Nemesure, Suh-Yuh Wu, M. Cristina Leske, Christine Neslund‐Dudas, Marian L. Neuhouser, Sarah J. Nyante, Heather M. Ochs‐Balcom, Adesola Ogunniyi, Temidayo O. Ogundiran, Oladosu Ojengbede, Olufunmilayo I. Olopade, Julie R. Palmer, Edward A. Ruiz‐Narváez, Nicholette D. Palmer, Michael F. Press, Evandine Rampersaud, Laura J. Rasmussen‐Torvik, Jorge L. Rodriguez‐Gil, Babatunde Salako, Eric E. Schadt, Ann G. Schwartz, Daniel Shriner, David S. Siscovick, Shad B. Smith, Sylvia Wassertheil‐Smoller, Elizabeth K. Speliotes, Margaret R. Spitz, Lara Sucheston, Herman A. Taylor, Bamidele O. Tayo, Margaret A. Tucker, David J. Van Den Berg, Digna R. Velez Edwards, Thomas J. Wang, John K. Wiencke, Thomas W. Winkler, John S. Witte, Margaret Wrensch, Xifeng Wu, James J. Yang, Albert M. Levin, Taylor Young, Neil A. Zakai, Mary Cushman, Krista A. Zanetti, Jing Hua Zhao, Wei Zhao, Yonglan Zheng, Jie Zhou, Regina G. Ziegler, Joseph M. Zmuda, Jyotika K. Fernandes, Gary S. Gilkeson, Diane L. Kamen, Kelly J. Hunt, Ida J. Spruill, Christine B. Ambrosone, Stefan Ambs, Donna K. Arnett, Larry D. Atwood, Diane M. Becker, Sonja I. Berndt, Leslie Bernstein, William J. Blot, Ingrid B. Borecki, Erwin P. Böttinger, Donald W. Bowden, Gregory L. Burke, Stephen J. Chanock, Stephen S. Rich, Jingzhong Ding, David Duggan, Michele K. Evans, Caroline S. Fox, W. Timothy Garvey, Jonathan P. Bradfield, Hákon Hákonarson, Struan F.A. Grant, Ann W. Hsing, Lisa W. Chu, Jennifer J. Hu, Dezheng Huo, Sue A. Ingles, Esther M. John, Joanne M. Jordan, Edmond K. Kabagambe, Sharon L. R. Kardia, Rick A. Kittles, Phyllis J. Goodman, Eric A. Klein, Laurence N. Kolonel, Loı̈c Le Marchand, Simin Liu, Barbara McKnight, Robert C. Millikan, Thomas H. Mosley, Badri Padhukasahasram, L. Keoki Williams, Sanjay R. Patel, Ulrike Peters, Curtis A. Pettaway, Patricia A. Peyser, Bruce M. Psaty, Susan Redline, Charles N. Rotimi, Benjamin A. Rybicki, Michèle M. Sale, Pamela J. Schreiner, Lisa B. Signorello, Andrew B. Singleton, Janet L. Stanford, Sara S. Strom, Michael J. Thun, Mara Z. Vitolins, Wei Zheng, Jason H. Moore, Scott M. Williams, Shamika Ketkar, Xiaofeng Zhu, Alan B. Zonderman, Charles Kooperberg, George Papanicolaou, Brian E. Henderson, Alex P. Reiner, Joel N. Hirschhorn, Ruth J. F. Loos, Kari E. North, Christopher A. Haiman,

Cancer-related molecular mechanisms research

Keri Monda, Kari North, Christopher Haiman and colleagues report a meta-analysis of GWAS for body mass index that is composed of 39,144 individuals of African ancestry, followed by further genotyping in 32,268 individuals of African ancestry. The study also includes analysis of publicly available data from the GIANT consortium of ~124,000 individuals of European ancestry. The paper reports evidence for two new loci near GALNT10 and MIR148A. Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10−11) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10−10). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 × 10−8). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 × 10−7), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations.