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BIBTEX RIS

High-speed atomic force microscopy coming of age

2012; IOP Publishing; Volume: 23; Issue: 6 Linguagem: Inglês

10.1088/0957-4484/23/6/062001

ISSN

1361-6528

Autores

Toshio Ando,

Tópico(s)

Lipid Membrane Structure and Behavior

Resumo

High-speed atomic force microscopy (HS-AFM) is now materialized. It allows direct visualization of dynamic structural changes and dynamic processes of functioning biological molecules in physiological solutions, at high spatiotemporal resolution. Dynamic molecular events unselectively appear in detail in an AFM movie, facilitating our understanding of how biological molecules operate to function. This review describes a historical overview of technical development towards HS-AFM, summarizes elementary devices and techniques used in the current HS-AFM, and then highlights recent imaging studies. Finally, future challenges of HS-AFM studies are briefly discussed.

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