Portal de Periódicos da CAPES

Biochemical Characteristics and Regulation of Brain α 2 ‐Adrenoceptors a

1984; Wiley; Volume: 430; Issue: 1 Linguagem: Inglês

10.1111/j.1749-6632.1984.tb14498.x

1749-6632

David C. U’Prichard,

Neuroendocrine regulation and behavior

Annals of the New York Academy of SciencesVolume 430, Issue 1 p. 55-75 Biochemical Characteristics and Regulation of Brain α2-Adrenoceptorsa DAVID C. U'PRICHARD, DAVID C. U'PRICHARD Nova Pharmaceutical Corporation Baltimore, Maryland 21228Search for more papers by this author DAVID C. U'PRICHARD, DAVID C. U'PRICHARD Nova Pharmaceutical Corporation Baltimore, Maryland 21228Search for more papers by this author First published: June 1984 https://doi.org/10.1111/j.1749-6632.1984.tb14498.xCitations: 28 a The work reported here was supported in part by Grants NS15595, DA02763, MH36183, MH32842, NS18639, and NS09919 from the U.S. Public Health Service. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 Starke, K., T. Endo & H. D. Taube. 1975. Relative pre- and post-synaptic potencies of α-adrenoceptor agonists in the rabbit pulmonary artery. Naunyn Schmiedeberg's Arch. Pharmacol. 291: 55–78. 2 Taube, H. D., K. Stark & E. Borowski. 1977. Presynaptic receptor systems on the noradrenergic neurons of rat brain. Naunyn Schmiedeberg's Arch. Pharmacol. 299: 123–141. 3 Langer, S. Z. 1974. Presynaptic regulation of catecholamine release. Biochem. Pharmacol. 23: 1793–1800. 4 Jakobs, K. H., W. Saur & G. Schultz. 1976. Reduction of adenylate cyclase activity in lysates of human platelets by the alpha-adrenergic component of epinephrine. J. Cyclic Nucl. Res. 2: 381–392. 5 Jakobs, K. H., K. Aktories & G. Schultz. 1983. Inhibitory coupling of hormone and neurotransmitter receptors to adenylate cyclase. J. Receptor Res. 3: 137–149. 6 Yamazaki, S., T. Katada & M. Ui. 1982. Alpha2-adrenergic inhibition of insulin secretion via interference with cyclic AMP generation in rat pancreatic islets. Mol. Pharmacol. 21: 648–653. 7 Kahn, D. J., J. C. Mitrius & D. C. U'Prichard. 1982. Alpha2-adrenergic receptors in neuroblastoma × glioma hybrid cells: Characterization with agonist and antagonist radioligands and relationship to adenylate cyclase. Mol. Pharmacol. 21: 17–26. 8 Fain, J. N. & J. A. Garcia-Sainz. 1980. Role of phosphatidylinositol turnover in alpha-1 and of adenylate cyclase inhibition in the alpha-2 effects of catecholamines. Life Sci. 26: 1183–1194. 9 Charest, R., R. F. Blackmore, B. Berton & J. H. Exton. 1983. Changes in free cytosolic Ca2+ in hypatocytes following α1-adrenergic stimulation: Studies with Quin-2-loaded hepatocytes. J. Biol. Chem. 258: 8769–8773. 10 Limbird, L. E. 1981. Activation and attenuation of adenylate cyclase. Biochem. J. 195: 1–13. 11 Greenberg, D. A., D. C. U'Prichard & S. H. Snyder. 1976. Alpha-noradrenergic receptor binding in mammalian brain: Differential labeling of agonist and antagonist states. Life Sci. 19: 69–76. 12 U'Prichard, D. C., D. A. Greenberg & S. H. Snyder. 1977. Binding characteristics of a radiolabeled agonist and antagonist at central nervous system alpha-noradrenergic receptors. Mol. Pharmacol. 13: 454–473. 13 U'Prichard, D. C. & S. H. Snyder. 1979. Distinct α-noradrenergic receptors identified by binding and physiological relationships. Life Sci. 24: 79–88. 14 Bylund, D. B. & D. C. U'Prichard. 1983. Characterization of alpha-1 and alpha-2 adrenergic receptors. Int. Rev. Neurobiol. 24: 343–431. 15 Atlas, D. & S. L. Sabol. 1981. Interaction of clonidine and clonidine analogues with alpha-adrenergic receptors of neuroblastoma × glioma hybrid cells and rat brain. Eur. J. Biochem. 113: 521–529. 16 U'Prichard, D. C. & S. H. Snyder. 1977. Binding of [3H]catecholamines to α-noradrenergic receptors in calf brain. J. Biol. Chem. 252: 6450–6463. 17 U'Prichard, D. C., W. B. Bechtel, B. Rouot & S. H. Snyder. 1979. Multiple alpha-noradrenergic receptor binding sites in rat brain: Effect of 6-hydroxydopamine. Mol. Pharmacol. 16: 47–60. 18 Kent, R. S., A. DeLean & R. J. Lefkowitz. 1980. A quantitative analysis of beta-adrenergic receptor interactions: Resolution of high and low affinity states of the receptor by computer modeling of ligand binding data. Mol. Pharmacol. 17: 14–23. 19 Glossman, H. & P. Presek. 1979. Alpha-noradrenergic receptors in brain membranes: Sodium, magnesium and guanyl nucleotides modulate agonist binding. Naunyn Schmiedeberg's Arch. Pharmacol. 306: 67–73. 20 Glossmann, H. & R. Hornung. 1980. Alpha2-adrenoceptors in brain: The divalent cation site. Naunyn-Schmiedeberg's Arch. Pharmacol. 314: 101–109. 21 Braunwalder, A., G. Stone & R. A. Lovell. 1981. Characterization of [3H]clonidine binding to two sites in calf brain membranes. J. Neurochem. 37: 70–78. 22 Rouot, B., D. C. U'Prichard & S. H. Snyder. 1980. Multiple alpha2-adrenergic receptor sites in rat brain: Selective regulation of high affinity [3H]clonidine binding by guanine nucleotides and divalent cations. J. Neurochem. 34: 374–384. 23 Salama, A. I., L. L. Lin, L. D. Repp & D. C. U'Prichard. 1982. Magnesium reduces affinities of antagonists at rat cerebral cortex alpha2-adrenergic receptors labeled with [3H]clonidine: Evidence for heterogeneity of alpha2-receptor conformations with respect to antagonists. Life Sci. 30: 1305–1311. 24 U'Prichard, D. C. & S. H. Snyder. 1980. Interactions of divalent cations and guanine nucleotides at α2-noradrenergic receptor binding sites in bovine brain membranes. J. Neurochem. 34: 385–394. 25 Perry, B. D. & D. C. U'Prichard. 1984. Regional distribution of α2-adrenergic receptor affinity states in human, bovine and rat brain: further evidence for an allosteric model of α2-receptor-ligand interactions and brain regional variation in α2-receptor/effector coupling. Brain Res.: in press. 26 Cheung, Y. D., D. B. Barnett & S. R. Nahorski. 1982. [3H]Rauwolscine and [3H]yohimbine binding to rat cerebral and human platelet membranes: possible heterogeneity of α2-adrenoceptors. Eur. J. Pharmacol. 84: 79–85. 27 Rouot, B., M. C. Quennedey & J. Schwartz. 1982. Characteristics of the [3H]yohimbine binding on rat brain α2-adrenoceptors. Naunyn Schmiedeberg's Arch. Pharmacol. 321: 253–259. 28 Woodcock, E. A. & B. Murley. 1982. Increased central α2-adrenergic receptors measured with [3H]yohimbine in the presence of sodium ion and guanyl nucleotides. Biochem. Biophys. Res. Commun. 105: 252–258. 29 Perry, B. D. & D. C. U'Prichard. 1981. [3H]Rauwolscine (α-yohimbine): A specific antagonist radioligand for brain α2-adrenergic receptors. Eur. J. Pharmacol. 76: 460–464. 30 Diop, L., J.-P. Dausse & P. Meyer. 1983. Specific binding of [3H]rauwolscine to α2-adrenoceptors in rat cerebral cortex: Comparison between crude and synaptosomal plasma membranes. J. Neurochem. 41: 710–715. 31 U'Prichard, D. C., J. C. Mitrius, D. J. Kahn & B. D. Perry. 1983. The α2-adrenergic receptor: Multiple affinity states and regulation of a receptor inversely coupled to adenylate cyclase. In Molecular Pharmacology of Neurotransmitter Receptors. T. Segawa et al., Eds.: 53–72. Raven Press. New York , NY. . 32 Hoffman, B. B., D. M. Kilpatrick & R. J. Lefkowitz. 1980. Heterogeneity of radioligand binding to α-adrenergic receptors: Analysis of guanine nucleotide regulation of agonist binding in relation to receptor subtypes. J. Biol. Chem. 255: 4645–4652. 33 Colquhoun, D. 1973. The relation between classical and cooperative models for drug action. In Drug Receptors. H. P. Rang, Ed.: 149–182. University Park Press. Baltimore , Md. . 34 DeLean, A., B. F. Kilpatrick & M. G. Caron. 1982. Dopamine receptor of the porcine anterior pituitary gland: Evidence for two affinity states discriminated by both agonists and antagonists. Mol. Pharmacol. 22: 290–297. 35 U'Prichard, D. C. & S. H. Snyder. 1978. [3H]Catecholamine binding to alpha-receptors in rat brain: Enhancement by reserpine. Eur. J. Pharmacol. 51: 145–155. 36 U'Prichard, D. C., T. D. Reisine, S. T. Mason, H. T. Fibiger & H. I. Yamamura. 1980. Modulation of rat brain α2- and α1-adrenergic receptor populations by lesion of the dorsal noradrenergic bundle. Brain Res. 187: 143–154. 37 Wang, C. H. & D. C. U'Prichard. 1984. Effects of congenital noradrenergic hyperinnervation and subsequent denervation on rat cortex adrenergic receptor subtypes. J. Neurosci.: In press. 38 Johnston, M. V., R. Grzanna & J. T. Coyle. 1979. Methylazoxymethanol treatment of fetal rats results in abnormally dense noradrenergic innervation of neocortex. Science 203: 369–371. 39 Mitrius, J. C. & D. C. U'Prichard. 1984. Regulation of alpha2-adrenoceptors by nucleotides, ions and agonists: Comparison in cells of neural and non-neural origin. Adv. Cyclic Nucl. Res. 18: in press. 40 U'Prichard, D. C., K. M. Braas & D. J. Kahn. 1982. In vitro models to examine regulation of transmitter content and adenylate cyclase coupled receptors in neurons. Psychopharmacol. Bull. 18: 180–183. 41 Su, Y. F., T. K. Harden & J. P. Perkins. 1980. Catecholamine-specific desensitization of adenylate cyclase: Evidence for a multi-step process. J. Biol. Chem. 255: 7410–7419. 42 Sabol, S. & M. Nirenberg. 1979. Regulation of adenylate cyclase of neuroblastoma × glioma hybrid cells by alpha-adrenergic receptors. II. Long-lived increase of adenylate cyclase activity mediated by alpha receptors. J. Biol. Chem. 254: 1921–1926. 43 U'Prichard, D. C., C. H. Wang & C. R. Freed. 1981. Brain monoamine receptor changes associated with catecholamine depletion and hypotension during continuous α-methyldopa infusion. Neurosci. Soc. Abstr. 7: 427. 44 Freed, C. R., C. H. Wang & D. C. U'Prichard. 1984. Regional brain metabolism of α-methyldopa and changes in alpha receptor number after long term α-methyldopa administration to spontaneously hypertensive rats. In Central Alpha Adrenergic Blood Pressure Regulating Mechanisms. W. B. Abrams & C. S. Sweet, Eds., Hypertension: In press. 45 Maggi, A., D. C. U'Prichard & S. J. Enna. 1980. Beta-adrenergic regulation of alpha2-adrenergic receptors in the central nervous system. Science 207: 645–647. 46 Wang, C. H. & D. C. U'Prichard. 1980. Reciprocal alterations in rat brain β and α2-adrenergic receptor sites after chronic intraventricular infusion of isoproterenol. Neurosci. Soc. Abstr. 6: 1. 47 Wang, C. H. & D. C. U'Prichard. Concurrent alterations in rat cerebral cortex beta and alpha2 drenergic receptors after chronic intracerebroventricular infusion of isoproterenol. Submitted for publication. 48 Hildebrandt, J. D., R. D. Sekura, J. Codina, R. Iyengar, C. R. Manclark & L. Birnbaumer. 1983. Stimulation and inhibition of adenylyl cyclases mediated by distinct regulatory proteins. Nature 302: 706–709. 49 Codina, J., J. Hildebrandt, R. Iyenger, L. Birnbaumer, R. D. Sekura & C. R. Manclark. 1983. Pertussis toxin substrate, the putative Ni component of adenyl cyclases, is an heterodimer regulated by guanine nucleotide and magnesium. Proc. Natl. Acad. Sci. USA 80: 4276–4280. 50 Perry, B. D., J. M. Stolk, G. Vantini, R. Guchhait & D. C. U'Prichard. 1983. Strain differences in rat brain epinephrine synthesis and α-adrenergic receptor number: Apparent in vivo regulation of brain α-adrenergic receptors by epinephrine. Science 221: 1297–1299. 51 Stolk, J. M., G. Vantini, R. B. Guchhait, J. H. Hurst, B. D. Perry, D. C. U'Prichard & R. C. Elston. 1984. Inheritance of adrenal phenylethanolamine N-methyltransferase activity in the rat. Genetics: In press. 52 Vantini, G., B. D. Perry, R. B. Guchhait, D. C. U'Prichard & J. M. Stolk. 1984. Brain epinephrine systems: Detailed comparison of adrenergic and noradrenergic metabolism, and receptor number and in vitro regulation, in two inbred rat strains. Brain Res. 296: 49–65. 53 Stolk, J. M., G. Vantini, B. D. Perry, R. B. Guchhait & D. C. U'Prichard. 1984. Assessment of the functional role of brain adrenergic neurons: Chronic effects of phenylethanolamine N-methyltransferase inhibitors and alpha-adrenergic receptor antagonists on brain norepinephrine metabolism. J. Pharmacol. Exp. Ther.: in press. 54 Raiteri, M., G. Maura & P. Versace. 1983. Functional evidence of two stereochemically different alpha-2 adrenoceptors regulating central norepinephrine and serotonin release. J. Pharmacol. Exp. Ther. 224: 679–684. 55 Svensson, T. H. & G. Engberg. 1980. Putative regulation of brain norepinephrine neurons by epinephrine: Electrophysiological studies. In Central Adrenaline Neurons, Basic Aspects, and Their Role in Cardiovascular Function. K. Fuxe, M. Goldstein, B. Hokfeldt and T. Hokfeldt, Eds.: 105–111. Pergamon Press. Oxford . 56 Young, W. S. & M. J. Kuhar. 1980. Noradrenergic α1 and α2 receptors: Light microscopic autoradiographic localization. Proc. Natl. Acad. Sci. USA 77: 1696–1700. Citing Literature Volume430, Issue1Presynaptic Modulation of Postsynaptic Modulation in Mental DiseasesJune 1984Pages 55-75 ReferencesRelatedInformation