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'Acute on chronic' effect of depot leuprolide in patients with stage D2 cancer of prostate

1990; Lippincott Williams & Wilkins; Volume: 1; Issue: 1 Linguagem: Inglês

10.1097/00001813-199010000-00005

1473-5741

Roohollah Sharifi, Mark S. Soloway, Michael Clayton, Assaad M. Mounzer, Marion Strub, Paul Siami, M. Lee,

Cancer, Lipids, and Metabolism

During a phase III open study of depot leuprolide for stage D2 cancer of the prostate, we studied the effect of depot leuprolide on chronic leuprolide users. To determine whether there was a transient elevation of testosterone or luteinizing hormone (LH) 4–24 h and 3–5 days following the monthly injections, we monitored the changes of testosterone and LH before injection and 24 h post-injection in 10 patients who have been under depot leuprolide Rx for 24–36 weeks, and in 35 patients before injection and 3–5 days post-injection who have received depot leuprolide for 8–24 weeks prior to monitoring. Comparison of the data between pre-injection within 24 h and 3–5 days post-injection showed no significant changes of testosterone and LH values between these levels for either testosterone (P = 0.31) or LH (P = 0.45). We therefore conclude that there was no 'acute on chronic' effect of depot formulation in chronic users of depot leuprolide.