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Phagosome maturation: going through the acid test

2008; Nature Portfolio; Volume: 9; Issue: 10 Linguagem: Inglês

10.1038/nrm2515

1471-0080

Jason M. Kinchen, Kodi S. Ravichandran,

Erythrocyte Function and Pathophysiology

Phagosome maturation is the process by which a particle-containing phagosome 'matures' through a series of increasingly acidic membrane-bound structures, becoming an acidic phagolysosome before fusing with lysosomes. The identification of a pathway for apoptotic cell-containing phagosomes reveals parallels and differences with receptor-mediated endocytosis. Phagosome maturation is the process by which internalized particles (such as bacteria and apoptotic cells) are trafficked into a series of increasingly acidified membrane-bound structures, leading to particle degradation. The characterization of the phagosomal proteome and studies in model organisms and mammals have led to the identification of numerous candidate proteins that cooperate to control the maturation of phagosomes containing different particles. A subset of these candidate proteins makes up the first pathway to be identified for the maturation of apoptotic cell-containing phagosomes. This suggests that a machinery that is distinct from receptor-mediated endocytosis is used in phagosome maturation.