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Effect of C1-esterase-inhibitor on capillary leak and inflammatory response syndrome during arterial switch operations in neonates

2001; Elsevier BV; Volume: 15; Issue: 4 Linguagem: Inglês

10.1053/jcan.2001.24989

1532-8422

Peter Tassani, R. Kunkel, J Richter, Hannelore Oechsler, H.-P. Lorenz, Siegmund Braun, Gregory P. Eising, Felix Haas, Sun U. Paek, Robert Bauernschmitt, Marianne Jochum, Rüdiger Lange,

Hyperglycemia and glycemic control in critically ill and hospitalized patients

Objective: To determine if prophylactic administration of C1-esterase-inhibitor would have a beneficial effect on postoperative weight gain and the inflammatory response in neonates undergoing cardiac surgery with cardiopulmonary bypass (CPB). Design: Randomized, double-blinded study. Setting: University-affiliated heart center. Participants: Twenty-four neonates with transposition of the great arteries. Interventions: In group inhibitor (INH) patients (n = 12), 100 IU/kg of C1-esterase-inhibitor (Berinert) was given 30 minutes before CPB. In group placebo (P) patients (n = 12), placebo was administered instead. Interleukin (IL)-6, C3a anaphylatoxin, C1 activity, prekallikrein, Hageman factor, D-dimers, and clinical parameters were measured 6 times perioperatively. Measurements and Main Results: All 24 patients had an uneventful clinical course. Mean arterial pressure and pulmonary oxygenation after CPB were superior in group INH patients. The weight gain on postoperative days 1 to 4 was significantly less in group INH patients compared with group P (55 ± 59 g vs. 340 ± 121 g, day 1). The concentration of IL-6 (76 ± 17 pg/mL vs. 262 ± 95 pg/mL during CPB) was significantly lower in group INH patients compared with group P patients. In contrast, no influence on C3a anaphylatoxin and coagulation factors was found. Conclusion: Prophylactic application of C1-esterase-inhibitor in neonates undergoing arterial switch operations produces less inflammatory response compared with placebo. This difference may have contributed to improved clinical parameters, including less weight gain postoperatively. Copyright © 2001 by W.B. Saunders Company