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Actinic reticuloid

1989; Elsevier BV; Volume: 21; Issue: 2 Linguagem: Inglês

10.1016/s0190-9622(89)70162-6

1097-6787

Johan Toonstra, C. J. M. Henquet, H. van Weelden, S. C. J. van der Putte, W.A. van Vloten,

Allergic Rhinitis and Sensitization

We report a detailed clinical, histopathologic, and photobiologic study of 16 Dutch patients with actinic reticuloid. All were middle-aged or elderly men who had persistent plaques on light-exposed skin only (two patients), extension of lesions to nonexposed areas (four patients), or prolonged or persistent episodes of erythroderma (10 patients). They were sensitive to UVB, UVA, and visible light. In 10 of 13 patients tested, the dermal infiltrate contained predominantly suppressor T cells. Many also had a reversed helper-suppressor T cell ratio. Circulating lymphocytes with deeply indented nuclei were present in all but were most pronounced in the most photosensitive erythrodermic patients. Tolerance induction therapy with UVB irradiation produced an excellent or good response in 13 of 15 patients. One patient responded to cyclosporine therapy.