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A proposed biosynthesis pathway of drosopterins in Drosophila melanogaster

1976; Elsevier BV; Volume: 22; Issue: 3 Linguagem: Inglês

10.1016/0022-1910(76)90012-3

1879-1611

Giuseppe Parisi, M. Carfagna, D D'Amora,

Gout, Hyperuricemia, Uric Acid

Some ommochrome-deficient mutants of Drosophila melanogaster (v, cn, cd, and st) the xanthine NAD-oxidoreductase-deficient mal mutant, and the double mutants mal v, mal cn, mal cd, and mal st, were analysed for their drosopterin content. Results indicate that xanthommatin and NAD+ are involved as cofactors in the transformation process of 7,8-dihydrobiopterin into sepiapterin. A metabolic pathway model for drosopterin biosynthesis that explains the different pterin contents of the mutants studied is now proposed.