Effect of chlorpromazine on central nervous system concentrations of manganese, iron, and copper
1977; Elsevier BV; Volume: 20; Issue: 7 Linguagem: Inglês
10.1016/0024-3205(77)90490-8
ISSN1879-0631
AutoresWilliam J. Weiner, Paul A. Nausieda, Harold L. Klawans,
Tópico(s)Neuroscience and Neuropharmacology Research
ResumoChronic administration of chlorpromazine produced alterations in trace metal concentrations in caudate nucleus, frontal cortex, and cerebellar hemisphere of guinea pigs. Manganese concentration following chronic chlorpromazine rose significantly in the caudate nucleus and cerebellar hemisphere whereas iron concentration rose most significantly in the caudate nucleus. Copper content was decreased in all regions examined. The possible significance of increased manganese and iron in the caudate nucleus is discussed in relationship to the clinical problems of chlorpromazine-induced dyskinesias.
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