Mechanisms of chemoprotection by oltipraz
1992; Wiley; Volume: 50; Issue: S16I Linguagem: Inglês
10.1002/jcb.240501331
ISSN1097-4644
AutoresThomas Kensier, Peter Stcyzynski, John D. Groopman, Kathy J. Helzlsouer, Thomas J. Curphey, Yulla Maxcultenko, Bill D. Roebuck,
Tópico(s)Synthesis and Biological Evaluation
ResumoJournal of Cellular BiochemistryVolume 50, Issue S16I p. 167-172 Article Mechanisms of chemoprotection by oltipraz Thomas Kensier PhD, Thomas Kensier PhD Department of Environmental Health Sciences, Johns Hopkins Schol of Hygiene and Public Health, Baltimore, Maryland 21205Search for more papers by this authorPeter Stcyzynski PhD, Peter Stcyzynski PhD Department of Environmental Health Sciences, Johns Hopkins Schol of Hygiene and Public Health, Baltimore, Maryland 21205Search for more papers by this authorJohn Groopman PhD, John Groopman PhD Department of Environmental Health Sciences, Johns Hopkins Schol of Hygiene and Public Health, Baltimore, Maryland 21205Search for more papers by this authorKathy Helzlsouer MD, MHS, Kathy Helzlsouer MD, MHS Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore Maryland 21205Search for more papers by this authorThomas Curphey PhD, Thomas Curphey PhD Department of Pathology, Dartmouth Medical School, Hanover, New Hampshire 03755Search for more papers by this authorYulla Maxcultenko Ms, Yulla Maxcultenko Ms Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755Search for more papers by this authorB. D. Roebuck PhD, B. D. Roebuck PhD Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755Search for more papers by this author Thomas Kensier PhD, Thomas Kensier PhD Department of Environmental Health Sciences, Johns Hopkins Schol of Hygiene and Public Health, Baltimore, Maryland 21205Search for more papers by this authorPeter Stcyzynski PhD, Peter Stcyzynski PhD Department of Environmental Health Sciences, Johns Hopkins Schol of Hygiene and Public Health, Baltimore, Maryland 21205Search for more papers by this authorJohn Groopman PhD, John Groopman PhD Department of Environmental Health Sciences, Johns Hopkins Schol of Hygiene and Public Health, Baltimore, Maryland 21205Search for more papers by this authorKathy Helzlsouer MD, MHS, Kathy Helzlsouer MD, MHS Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore Maryland 21205Search for more papers by this authorThomas Curphey PhD, Thomas Curphey PhD Department of Pathology, Dartmouth Medical School, Hanover, New Hampshire 03755Search for more papers by this authorYulla Maxcultenko Ms, Yulla Maxcultenko Ms Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755Search for more papers by this authorB. D. Roebuck PhD, B. D. Roebuck PhD Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755Search for more papers by this author First published: 1992 https://doi.org/10.1002/jcb.240501331Citations: 23AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract 1,2-Dithiole-3-thiones are five-membered cyclic sulfur-containing compounds with antioxidant, chemotherapeutic, radioprotective and cancer chemopretective properties. One substituted dithiolethione, oltipraz [5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione], originally developed as an antischistosomal agent, has recently been observed to protect against chemically induced carcinogenesis in lung, trachea, forestomach, colon, breast, liver and urinary bladder in rodents. The induction of electrophilic detoxication enzymes, which result in diminisehd carcinogen-DNA adduct formation are reduced cytotoxicity, appears to be an important component of the anticarcinogenic action of oltipraz and other dithiolethiones. Phase I trials of oltipraz are presently underway in the United States. Subsequent trials might be most appropriately targeted towards individuals at high risk for occupational or environmental exposures to genotoxic carciongens. © 1992 Wiley-Liss, Inc. Citing Literature Volume50, IssueS16ISupplement: Chemoprevention of Premalignant and Early Malignant Lesions of the Bladder1992Pages 167-172 RelatedInformation
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