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Primary Prophylaxis of Invasive Fungal Diseases in Allogeneic Stem Cell Transplantation: Revised Recommendations from a Consensus Process by Gruppo Italiano Trapianto Midollo Osseo (GITMO)

2014; Elsevier BV; Volume: 20; Issue: 8 Linguagem: Inglês

10.1016/j.bbmt.2014.02.018

1523-6536

Corrado Girmenia, Giovanni Barosi, Alfonso Piciocchi, William Arcese, Franco Aversa, Andrea Bacigalupo, Giuseppe Bandini, Alberto Bosi, Alessandro Busca, Elio Castagnola, Désirée Caselli, Simone Cesaro, Fabio Ciceri, Anna Locasciulli, Franco Locatelli, Małgorzata Mikulska, Livio Pagano, Arcangelo Prete, Anna Maria Raiola, Alessandro Rambaldi,

Infectious Diseases and Mycology

This document updates and expands the recommendations on primary prophylaxis of invasive fungal diseases (IFD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients, published in 2009 by the Gruppo Italiano Trapianto Midollo Osseo (GITMO). A consensus process was undertaken to describe and evaluate current information and practice regarding risk stratification and primary antifungal prophylaxis during the pre-engraftment and postengraftment phases after allo-HSCT. The revised recommendations were based on the evaluation of recent literature including a large, prospective, multicenter epidemiological study of allo-HSCT recipients conducted among the GITMO transplantation centers during the period of 2008 to 2010. It is intended as a guide for the identification of types and phases of transplantation at low, standard, and high risk for IFD, according to the underlying disease, transplantation, and post-transplantation factors. The risk stratification was the critical determinant of the primary antifungal approach for allo-HSCT recipients.