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Cellular Fibronectin Expression in Human Trabecular Meshwork and Induction by Transforming Growth Factor-β2

2013; Cadmus Press; Volume: 54; Issue: 10 Linguagem: Inglês

10.1167/iovs.13-12298

1552-5783

Wanda E. Medina‐Ortiz, Ricardo Belmares, Stefan Neubauer, Robert J. Wordinger, Abbot F. Clark,

Corneal surgery and disorders

Purpose.: Levels of TGF-β2 are higher in POAG aqueous humor, causing deposition of extracellular matrix (ECM) proteins, including fibronectin (FN), in the glaucomatous human trabecular meshwork (HTM) that may be responsible for elevated IOP. The purpose of this study was to identify the expression of cellular FN (cFN) isoforms (EDA and EDB) in HTM cells and tissues, and to determine whether TGF-β2 can induce cFN expression and fibril formation in cultured HTM cells.