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Antibiotics from neglected bacterial sources

2013; Elsevier BV; Volume: 304; Issue: 1 Linguagem: Inglês

10.1016/j.ijmm.2013.08.011

1618-0607

Sacha J. Pidot, Sébastien Coyne, Florian Kloß, Christian Hertweck,

Alkaloids: synthesis and pharmacology

The current crop of antibiotics in clinical use are either natural products or their derivatives. However, the rise of a multitude of different antibiotic resistant human pathogens has meant that new antibiotics are urgently needed. Unfortunately, the search for new antibiotics from traditional bacterial sources often results in a high rediscovery rate of known compounds and a low chance of identifying truly novel chemical entities. To overcome this, previously unexplored (or under investigated) bacterial sources are being tapped for their potential to produce novel compounds with new activities. Here, we review a number of antibiotic compounds identified from bacteria of the genera Burkholderia, Clostridium, Lysobacter, Pantoea and Xenorhabdus and describe the potential of organisms and their associated metabolites in future drug discovery efforts.