Occurrence of the Yersinia high-pathogenicity island and iron uptake systems in clinical isolates of Klebsiella pneumoniae
2003; Elsevier BV; Volume: 35; Issue: 5 Linguagem: Inglês
10.1016/s0882-4010(03)00125-6
ISSN1096-1208
AutoresRyszard Koczura, Adam Kaznowski,
Tópico(s)Bacterial biofilms and quorum sensing
ResumoThe ability to acquire iron is crucial to bacteria during an infection. Thirty-four strains of Klebsiella pneumoniae isolated from clinical specimens were examined for the use of various strategies to obtain iron. The isolates employed several iron uptake mechanisms, including production of enterobactin (100%) and aerobactin (50%). Few isolates (18%) produced yersiniabactin, a siderophore encoded by the Yersinia high-pathogenicity island (HPI) despite genetic diversity of the HPI. Majority of the isolates used human transferrin (74%), lactoferrin (97%), hemoglobin (74%), and hemoglobin–haptoglobin complex (56%) as a sole source of iron. Multiple iron uptake systems may be of benefit to the bacteria during infection.
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